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10.4161/21624011.2014.941742

http://scihub22266oqcxt.onion/10.4161/21624011.2014.941742
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C4292522!4292522!25610725
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suck abstract from ncbi

pmid25610725      Oncoimmunology 2014 ; 3 (7): ä
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  • Lenalidomide induces degradation of IKZF1 and IKZF3 #MMPMID25610725
  • Krönke J; Hurst SN; Ebert BL
  • Oncoimmunology 2014[]; 3 (7): ä PMID25610725show ga
  • Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to degrade the lymphoid transcription factors IKZF1 (Ikaros) and IKZF3 (Aiolos).
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