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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Oncoimmunology 2014 ; 3 (9): ä Nephropedia Template TP
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Vitamin B6 improves the immunogenicity of cisplatin-induced cell death #MMPMID25941619
Aranda F; Bloy N; Galluzzi L; Kroemer G; Senovilla L
Oncoimmunology 2014[]; 3 (9): ä PMID25941619show ga
We have recently demonstrated that pyridoxine, a precursor of vitamin B6, increases the immunogenicity of non-small cell lung carcinoma (NSCLC) cells succumbing to cisplatin (cis-diamminedichloroplatinum(II), CDDP). Accordingly, pyridoxine promoted the antineoplastic activity of CDDP in NSCLC-bearing mice only in the presence of an intact immune system. These findings may have implications for the development of novel strategies to circumvent CDDP resistance.