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10.4161/21624011.2014.947871

http://scihub22266oqcxt.onion/10.4161/21624011.2014.947871
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C4292413!4292413!25610734
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suck abstract from ncbi


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pmid25610734      Oncoimmunology 2014 ; 3 (7): ä
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  • Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion #MMPMID25610734
  • Mao CP; Wu T; Song KH; Kim TW
  • Oncoimmunology 2014[]; 3 (7): ä PMID25610734show ga
  • Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.
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