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Mechanism and Regulation of Meiotic Recombination Initiation #MMPMID25324213
Lam I; Keeney S
Cold Spring Harb Perspect Biol 2015[Jan]; 7 (1): ä PMID25324213show ga
Meiotic recombination involves the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent studies pertaining to the formation of meiotic DSBs, including the mechanism of DNA cleavage by Spo11, proteins required for break formation, and mechanisms that control the location, timing, and number of DSBs. Where appropriate, findings in different organisms are discussed to highlight evolutionary conservation or divergence.