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10.1101/cshperspect.a022913 http://scihub22266oqcxt.onion/10.1101/cshperspect.a022913 C4292159!4292159!25359498     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cold+Spring+Harb+Perspect+Biol 2014 ; 6 (12): ä Nephropedia Template TP {{tp|p=25359498|t=2014. Signal Transduction: From the Atomic Age to the Post-Genomic Era |pdf=|usr=}}{{25359498}} gab.com Text Signal Transduction: From the Atomic Age to the Post-Genomic Era JO: Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=25359498 #FOAvip We have come a long way in the 55 years since Edmond Fischer and the late Edwin Krebs discovered that the activity of glycogen phosphorylase is regulated by reversible protein phosphorylation. Many of the fundamental molecular mechanisms that operate in biological signaling have since been characterized and the vast web of interconnected pathways that make up the cellular signaling network has been mapped in considerable detail. Nonetheless, it is important to consider how fast this field is still moving and the issues at the current boundaries of our understanding. One must also appreciate what experimental strategies have allowed us to attain our present level of knowledge. We summarize here some key issues (both conceptual and methodological), raise unresolved questions, discuss potential pitfalls, and highlight areas in which our understanding is still rudimentary. We hope these wide-ranging ruminations will be useful to investigators who carry studies of signal transduction forward during the rest of the 21st century. Twit Text FOAVip Signal Transduction: From the Atomic Age to the Post-Genomic Era ????Cold Spring Harb Perspect Biol http://www.kidney.de/pget.php?&tw=1&pmid=25359498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25359498 #FOAvip English Wikipedia <ref>{{Cite pmid|25359498}}</ref> Signal Transduction: From the Atomic Age to the Post-Genomic Era #MMPMID25359498 Thorner J; Hunter T; Cantley LC; Sever R Cold Spring Harb Perspect Biol 2014[Dec]; 6 (12): ä PMID25359498show ga We have come a long way in the 55 years since Edmond Fischer and the late Edwin Krebs discovered that the activity of glycogen phosphorylase is regulated by reversible protein phosphorylation. Many of the fundamental molecular mechanisms that operate in biological signaling have since been characterized and the vast web of interconnected pathways that make up the cellular signaling network has been mapped in considerable detail. Nonetheless, it is important to consider how fast this field is still moving and the issues at the current boundaries of our understanding. One must also appreciate what experimental strategies have allowed us to attain our present level of knowledge. We summarize here some key issues (both conceptual and methodological), raise unresolved questions, discuss potential pitfalls, and highlight areas in which our understanding is still rudimentary. We hope these wide-ranging ruminations will be useful to investigators who carry studies of signal transduction forward during the rest of the 21st century. äSignal Transduction: From the Atomic Age to the Post-Genomic Era (epmc).pdf DeepDyve Pubget Overpricing