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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (1): 160-5 Nephropedia Template TP
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ETS transcription factor ETV2 directly converts human fibroblasts into functional endothelial cells #MMPMID25540418
Morita R; Suzuki M; Kasahara H; Shimizu N; Shichita T; Sekiya T; Kimura A; Sasaki Ki; Yasukawa H; Yoshimura A
Proc Natl Acad Sci U S A 2015[Jan]; 112 (1): 160-5 PMID25540418show ga
Endothelial cells (ECs) form vasculature to provide vital elements, such as nutrients and oxygen, to tissues and organs in the body. Thus, creating ECs from nonvascular cells by transducing some transcription factors not only leads to the development of new strategies for patient-specific therapeutic angiogenesis, but also facilitates the maintenance of the solid organs that are regenerated from pluripotent stem cells. In this paper, we show that the single transcription factor ETV2, which is lentivirally transduced, induces expression of the multiple EC-specific molecules in coordination with endogenous FOXC2 in the fibroblasts, resulting in the conversion of primary human adult skin fibroblasts into functional ECs that form mature perfused vessels in vivo.