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10.1073/pnas.1411761112 http://scihub22266oqcxt.onion/10.1073/pnas.1411761112 C4291626!4291626!25535347     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (1): 136-41 Nephropedia Template TP {{tp|p=25535347|t=2015. Helical buckling of actin inside filopodia generates traction |pdf=|usr=}}{{25535347}} gab.com Text Helical buckling of actin inside filopodia generates traction JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25535347 #FOAvip Filopodia are essential membrane protrusions that facilitate cellular sensing and interaction with the environment. The mechanical properties of filopodia are crucial for their ability to push and pull on external objects and are attributed to actin dynamics. We confirm the presence of F-actin inside extended filopodia and reveal a new mechanism by which actin can exert traction forces on external objects. This mechanism is mediated by rotation and helical buckling, which cause shortening and retraction of the actin shaft. By imaging of F-actin and simultaneous force spectroscopy, we reveal and detail how force propagates through this spiral actin structure and show how torsional twist of the actin shaft is translated into a traction force at the filopodial tip. Twit Text FOAVip Helical buckling of actin inside filopodia generates traction ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25535347 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25535347 #FOAvip English Wikipedia <ref>{{Cite pmid|25535347}}</ref> Helical buckling of actin inside filopodia generates traction #MMPMID25535347 Leijnse N; Oddershede LB; Bendix PM Proc Natl Acad Sci U S A 2015[Jan]; 112 (1): 136-41 PMID25535347show ga Filopodia are essential membrane protrusions that facilitate cellular sensing and interaction with the environment. The mechanical properties of filopodia are crucial for their ability to push and pull on external objects and are attributed to actin dynamics. We confirm the presence of F-actin inside extended filopodia and reveal a new mechanism by which actin can exert traction forces on external objects. This mechanism is mediated by rotation and helical buckling, which cause shortening and retraction of the actin shaft. By imaging of F-actin and simultaneous force spectroscopy, we reveal and detail how force propagates through this spiral actin structure and show how torsional twist of the actin shaft is translated into a traction force at the filopodial tip. äHelical buckling of actin inside filopodia generates traction (epmc).pdf DeepDyve Pubget Overpricing