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2014 ; 12
(10
): 1187-201
Nephropedia Template TP
gab.com Text
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English Wikipedia
Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and
future directions
#MMPMID25189526
Sebastian NT
; Collins KL
Expert Rev Anti Infect Ther
2014[Oct]; 12
(10
): 1187-201
PMID25189526
show ga
Current therapy for HIV effectively suppresses viral replication and prolongs
life, but the infection persists due, at least in part, to latent infection of
long-lived cells. One favored strategy toward a cure targets latent virus in
resting memory CD4(+) T cells by stimulating viral production. However, the
existence of an additional reservoir in bone marrow hematopoietic progenitor
cells has been detected in some treated HIV-infected people. This review
describes approaches investigators have used to reactivate latent proviral
genomes in resting CD4(+) T cells and hematopoietic progenitor cells. In
addition, the authors review approaches for clearance of these reservoirs along
with other important topics related to HIV eradication.