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10.1586/14787210.2014.956094

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suck abstract from ncbi


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pmid25189526
      Expert+Rev+Anti+Infect+Ther 2014 ; 12 (10 ): 1187-201
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  • Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions #MMPMID25189526
  • Sebastian NT ; Collins KL
  • Expert Rev Anti Infect Ther 2014[Oct]; 12 (10 ): 1187-201 PMID25189526 show ga
  • Current therapy for HIV effectively suppresses viral replication and prolongs life, but the infection persists due, at least in part, to latent infection of long-lived cells. One favored strategy toward a cure targets latent virus in resting memory CD4(+) T cells by stimulating viral production. However, the existence of an additional reservoir in bone marrow hematopoietic progenitor cells has been detected in some treated HIV-infected people. This review describes approaches investigators have used to reactivate latent proviral genomes in resting CD4(+) T cells and hematopoietic progenitor cells. In addition, the authors review approaches for clearance of these reservoirs along with other important topics related to HIV eradication.
  • |*Immunologic Memory [MESH]
  • |CD4-Positive T-Lymphocytes/immunology/*virology [MESH]
  • |HIV Infections/*drug therapy/immunology/virology [MESH]
  • |HIV/drug effects/immunology/*physiology [MESH]
  • |Hematopoietic Stem Cells/*immunology [MESH]
  • |Humans [MESH]
  • |Models, Immunological [MESH]
  • |Virus Latency [MESH]


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