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10.1002/ijc.29123 http://scihub22266oqcxt.onion/10.1002/ijc.29123 C4289421!4289421!25098665     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Cancer 2015 ; 136 (6): 1475-81 Nephropedia Template TP {{tp|p=25098665|t=2015. Neurotensin, a novel target of Wnt/?-catenin pathway, promotes growth of neuroendocrine tumor cells |pdf=|usr=}}{{25098665}} gab.com Text Neurotensin, a novel target of Wnt/ -catenin pathway, promotes growth of neuroendocrine tumor cells JO: Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25098665 #FOAvip Wnt/?-catenin signaling plays a pivotal role in regulating cell growth and differentiation by activation of the ?-catenin/T-cell factor (TCF) complex and subsequent regulation of a set of target genes that have one or more TCF-binding elements (TBEs). Hyperactivation of this pathway has been implicated in numerous malignancies including human neuroendocrine tumors (NETs). Neurotensin (NT), an intestinal hormone, induces proliferation of several gastrointestinal (GI) cancers including cancers of the pancreas and colon. Here, we analyzed the human NT promoter in silico and found at least four consensus TBEs within the proximal promoter region. Using a combination of ChIP and luciferase reporter assays, we identified one TBE (located approximately 900 bp proximal from the transcription start site) that was immunoprecipitated efficiently by TCF4-targeting antibody; mutation of this site attenuated the responsiveness to ?-catenin. We also confirmed that the promoter activity and the mRNA and protein expression levels of NT were increased by various Wnt pathway activators and decreased by Wnt inhibitors in NET cell lines BON and QGP-1, which express and secrete NT. Similarly, the intracellular content and secretion of NT were induced by Wnt3a in these cells. Finally, inhibition of NT signaling suppressed cell proliferation and anchorage-independent growth and decreased expression levels of growth-related proteins in NET cells. Our results indicate that NT is a direct target of the Wnt/?-catenin pathway and may be a mediator for NET cell growth. Twit Text FOAVip Neurotensin, a novel target of Wnt/ -catenin pathway, promotes growth of neuroendocrine tumor cells ????Int J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25098665 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25098665 #FOAvip English Wikipedia <ref>{{Cite pmid|25098665}}</ref> Neurotensin, a novel target of Wnt/?-catenin pathway, promotes growth of neuroendocrine tumor cells #MMPMID25098665 Kim JT; Liu C; Zaytseva YY; Weiss HL; Townsend CM; Evers BM Int J Cancer 2015[Mar]; 136 (6): 1475-81 PMID25098665show ga Wnt/?-catenin signaling plays a pivotal role in regulating cell growth and differentiation by activation of the ?-catenin/T-cell factor (TCF) complex and subsequent regulation of a set of target genes that have one or more TCF-binding elements (TBEs). Hyperactivation of this pathway has been implicated in numerous malignancies including human neuroendocrine tumors (NETs). Neurotensin (NT), an intestinal hormone, induces proliferation of several gastrointestinal (GI) cancers including cancers of the pancreas and colon. Here, we analyzed the human NT promoter in silico and found at least four consensus TBEs within the proximal promoter region. Using a combination of ChIP and luciferase reporter assays, we identified one TBE (located approximately 900 bp proximal from the transcription start site) that was immunoprecipitated efficiently by TCF4-targeting antibody; mutation of this site attenuated the responsiveness to ?-catenin. We also confirmed that the promoter activity and the mRNA and protein expression levels of NT were increased by various Wnt pathway activators and decreased by Wnt inhibitors in NET cell lines BON and QGP-1, which express and secrete NT. Similarly, the intracellular content and secretion of NT were induced by Wnt3a in these cells. Finally, inhibition of NT signaling suppressed cell proliferation and anchorage-independent growth and decreased expression levels of growth-related proteins in NET cells. Our results indicate that NT is a direct target of the Wnt/?-catenin pathway and may be a mediator for NET cell growth. äNeurotensin, a novel target of Wnt/?-catenin pathway, promotes growth (epmc).pdf DeepDyve Pubget Overpricing