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10.1021/ac502293p http://scihub22266oqcxt.onion/10.1021/ac502293p C4287828!4287828!25439269     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Anal+Chem 2015 ; 87 (1): 413-21 Nephropedia Template TP {{tp|p=25439269|t=2015. Analytical Characterization of the Role of Phospholipids in Platelet Adhesion and Secretion |pdf=|usr=}}{{25439269}} gab.com Text Analytical Characterization of the Role of Phospholipids in Platelet Adhesion and Secretion JO: Anal Chem http://www.kidney.de/pget.php?&tw=1&pmid=25439269 #FOAvip The cellular phospholipid membrane plays an important role in cell function and cell?cell communication, but its biocomplexity and dynamic nature presents a challenge for examining cellular uptake of phospholipids and the resultant effects on cell function. Platelets, small anuclear circulating cell bodies that influence a wide variety of physiological functions through their dynamic secretory and adhesion behavior, present an ideal platform for exploring the effects of exogenous phospholipids on membrane phospholipid content and cell function. In this work, a broad range of platelet functions are quantitatively assessed by leveraging a variety of analytical chemistry techniques, including ultraperformance liquid chromatography?tandem electrospray ionization mass spectrometry (UPLC?MS/MS), vasculature-mimicking microfluidic analysis, and single cell carbon-fiber microelectrode amperometry (CFMA). The relative enrichments of phosphatidylserine (PS) and phosphatidylethanolamine (PE) were characterized with UPLC?MS/MS, and the effects of the enrichment of these two phospholipids on both platelet secretory behavior and adhesion were examined. Results show that, in fact, both PS and PE influence platelet adhesion and secretion. PS was enriched dramatically and decreased platelet adhesion as well as secretion from ?-, ?-, and lysosomal granules. PE enrichment was moderate and increased secretion from platelet lysosomes. These insights illuminate the critical connection between membrane phospholipid character and platelet behavior, and both the methods and results presented herein are likely translatable to other mammalian cell systems. Twit Text FOAVip Analytical Characterization of the Role of Phospholipids in Platelet Adhesion and Secretion ????Anal Chem http://www.kidney.de/pget.php?&tw=1&pmid=25439269 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25439269 #FOAvip English Wikipedia <ref>{{Cite pmid|25439269}}</ref> Analytical Characterization of the Role of Phospholipids in Platelet Adhesion and Secretion #MMPMID25439269 Koseoglu S; Meyer A; Kim D; Meyer BM; Wang Y; Dalluge JJ; Haynes CL Anal Chem 2015[Jan]; 87 (1): 413-21 PMID25439269show ga The cellular phospholipid membrane plays an important role in cell function and cell?cell communication, but its biocomplexity and dynamic nature presents a challenge for examining cellular uptake of phospholipids and the resultant effects on cell function. Platelets, small anuclear circulating cell bodies that influence a wide variety of physiological functions through their dynamic secretory and adhesion behavior, present an ideal platform for exploring the effects of exogenous phospholipids on membrane phospholipid content and cell function. In this work, a broad range of platelet functions are quantitatively assessed by leveraging a variety of analytical chemistry techniques, including ultraperformance liquid chromatography?tandem electrospray ionization mass spectrometry (UPLC?MS/MS), vasculature-mimicking microfluidic analysis, and single cell carbon-fiber microelectrode amperometry (CFMA). The relative enrichments of phosphatidylserine (PS) and phosphatidylethanolamine (PE) were characterized with UPLC?MS/MS, and the effects of the enrichment of these two phospholipids on both platelet secretory behavior and adhesion were examined. Results show that, in fact, both PS and PE influence platelet adhesion and secretion. PS was enriched dramatically and decreased platelet adhesion as well as secretion from ?-, ?-, and lysosomal granules. PE enrichment was moderate and increased secretion from platelet lysosomes. These insights illuminate the critical connection between membrane phospholipid character and platelet behavior, and both the methods and results presented herein are likely translatable to other mammalian cell systems. äAnalytical Characterization of the Role of Phospholipids in Platelet A(epmc).pdf DeepDyve Pubget Overpricing