Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1161/STROKEAHA.114.007362 http://scihub22266oqcxt.onion/10.1161/STROKEAHA.114.007362 C4286169!4286169!25378430     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25378430&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Stroke 2014 ; 45 (12): 3589-96 Nephropedia Template TP {{tp|p=25378430|t=2014. Etiologic Ischemic Stroke Phenotypes in the NINDS Stroke Genetics Network |pdf=|usr=}}{{25378430}} gab.com Text Etiologic Ischemic Stroke Phenotypes in the NINDS Stroke Genetics Network JO: Stroke http://www.kidney.de/pget.php?&tw=1&pmid=25378430 #FOAvip Background and Purpose: NINDS Stroke Genetics Network (SiGN) is an international consortium of ischemic stroke studies that aims to generate high quality phenotype data to identify the genetic basis of etiologic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium. Methods: Fifty-two trained and certified adjudicators determined both phenotypic (abnormal test findings categorized in major etiologic groups without weighting towards the most likely cause) and causative ischemic stroke subtypes in 16,954 subjects with imaging-confirmed ischemic stroke from 12 US studies and 11 studies from 8 European countries using the web-based Causative Classification of Stroke System. Classification reliability was assessed with blinded re-adjudication of 1509 randomly selected cases. Results: The distribution of etiologic categories varied by study, age, sex, and race (p<0.001 for each). Overall, only 40% to 54% of cases with a given major ischemic stroke etiology (phenotypic subtype) were classified into the same final causative category with high confidence. There was good agreement for both causative (kappa 0.72, 95%CI:0.69-0.75) and phenotypic classifications (kappa 0.73, 95%CI:0.70-0.75). Conclusions: This study demonstrates that etiologic subtypes can be determined with good reliability in studies that include investigators with different expertise and background, institutions with different stroke evaluation protocols and geographic location, and patient populations with different epidemiological characteristics. The discordance between phenotypic and causative stroke subtypes highlights the fact that the presence of an abnormality in a stroke patient does not necessarily mean that it is the cause of stroke. Twit Text FOAVip Etiologic Ischemic Stroke Phenotypes in the NINDS Stroke Genetics Network ????Stroke http://www.kidney.de/pget.php?&tw=1&pmid=25378430 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25378430 #FOAvip English Wikipedia <ref>{{Cite pmid|25378430}}</ref> Etiologic Ischemic Stroke Phenotypes in the NINDS Stroke Genetics Network #MMPMID25378430 Ay H; Arsava EM; Andsberg G; Benner T; Brown RD; Chapman SN; Cole JW; Delavaran H; Dichgans M; Engström G; Giralt-Steinhauer E; Grewal RP; Gwinn K; Jern C; Jimenez-Conde J; Jood K; Katsnelson M; Kissela B; Kittner SJ; Kleindorfer DO; Labovitz DL; Lanfranconi S; Lee JM; Lehm M; Lemmens R; Levi C; Li L; Lindgren A; Markus HS; McArdle PF; Melander O; Norrving B; Peddareddygari LR; Pedersén A; Pera J; Rannikmäe K; Rexrode KM; Rhodes D; Rich SS; Roquer J; Rosand J; Rothwell PM; Rundek T; Sacco RL; Schmidt R; Schürks M; Seiler S; Sharma P; Slowik A; Sudlow C; Thijs V; Woodfield R; Worrall BB; Meschia JF Stroke 2014[Dec]; 45 (12): 3589-96 PMID25378430show ga Background and Purpose: NINDS Stroke Genetics Network (SiGN) is an international consortium of ischemic stroke studies that aims to generate high quality phenotype data to identify the genetic basis of etiologic stroke subtypes. This analysis characterizes the etiopathogenetic basis of ischemic stroke and reliability of stroke classification in the consortium. Methods: Fifty-two trained and certified adjudicators determined both phenotypic (abnormal test findings categorized in major etiologic groups without weighting towards the most likely cause) and causative ischemic stroke subtypes in 16,954 subjects with imaging-confirmed ischemic stroke from 12 US studies and 11 studies from 8 European countries using the web-based Causative Classification of Stroke System. Classification reliability was assessed with blinded re-adjudication of 1509 randomly selected cases. Results: The distribution of etiologic categories varied by study, age, sex, and race (p<0.001 for each). Overall, only 40% to 54% of cases with a given major ischemic stroke etiology (phenotypic subtype) were classified into the same final causative category with high confidence. There was good agreement for both causative (kappa 0.72, 95%CI:0.69-0.75) and phenotypic classifications (kappa 0.73, 95%CI:0.70-0.75). Conclusions: This study demonstrates that etiologic subtypes can be determined with good reliability in studies that include investigators with different expertise and background, institutions with different stroke evaluation protocols and geographic location, and patient populations with different epidemiological characteristics. The discordance between phenotypic and causative stroke subtypes highlights the fact that the presence of an abnormality in a stroke patient does not necessarily mean that it is the cause of stroke. äEtiologic Ischemic Stroke Phenotypes in the NINDS Stroke Genetics Netw(epmc).pdf DeepDyve Pubget Overpricing