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10.4049/jimmunol.1301945

http://scihub22266oqcxt.onion/10.4049/jimmunol.1301945
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C4285693!4285693!24890726
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suck abstract from ncbi


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pmid24890726      J+Immunol 2014 ; 193 (1): 26-9
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  • Parathyroid hormone (PTH) facilitates macrophage efferocytosis in bone marrow via pro-resolving mediators Resolvin D1 and Resolvin D2 #MMPMID24890726
  • McCauley LK; Dalli J; Koh AJ; Chiang N; Serhan CN
  • J Immunol 2014[Jul]; 193 (1): 26-9 PMID24890726show ga
  • Bone marrow macrophages stimulate skeletal wound repair and osteoblastic bone formation by as yet poorly defined mechanisms. Specialized pro-resolving mediators of inflammation drive macrophage efferocytosis (phagocytosis of apoptotic cells) and resolution but little is known regarding this process in the bone marrow. In the present report, metabololipidomic profiling via liquid chromatographic mass spectrometry revealed higher levels of specialized pro-resolving mediators (SPM) in the bone marrow relative to the spleen. The endocrine and bone anabolic agent parathyroid hormone (PTH) increased SPM levels including resolvins (Rv) in bone marrow. Human and murine primary macrophages efferocytosed apoptotic osteoblasts in vitro, and resolvin (Rv) D1 and RvD2 (10 pM-10 nM) enhanced this process. These findings support a unique profile of specialized lipid mediators in bone marrow that contributes to a feedback system for resolution of inflammation and maintenance of skeletal homeostasis.
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