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Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone
marrow via proresolving mediators resolvin D1 and resolvin D2
#MMPMID24890726
McCauley LK
; Dalli J
; Koh AJ
; Chiang N
; Serhan CN
J Immunol
2014[Jul]; 193
(1
): 26-9
PMID24890726
show ga
Bone marrow macrophages stimulate skeletal wound repair and osteoblastic bone
formation by poorly defined mechanisms. Specialized proresolving mediators of
inflammation drive macrophage efferocytosis (phagocytosis of apoptotic cells) and
resolution, but little is known regarding this process in the bone marrow. In
this study, metabololipidomic profiling via liquid chromatography mass
spectrometry revealed higher levels of specialized proresolving mediators in the
bone marrow relative to the spleen. The endocrine and bone anabolic agent
parathyroid hormone increased specialized proresolving mediator levels, including
resolvins (Rvs), in bone marrow. Human and murine primary macrophages
efferocytosed apoptotic osteoblasts in vitro, and RvD1 and RvD2 (10 pM-10 nM)
enhanced this process. These findings support a unique profile of specialized
lipid mediators in bone marrow that contribute to a feedback system for
resolution of inflammation and maintenance of skeletal homeostasis.
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