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10.1073/pnas.1409404111 http://scihub22266oqcxt.onion/10.1073/pnas.1409404111 C4284570!4284570!25468965     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (52): 18496-500 Nephropedia Template TP {{tp|p=25468965|t=2014. Physical basis of spindle self-organization |pdf=|usr=}}{{25468965}} gab.com Text Physical basis of spindle self-organization JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468965 #FOAvip The spindle segregates chromosomes during cell division and is composed of microtubules and hundreds of other proteins, but the manner in which these molecular constituents self-organize to form the spindle remains unclear. Here we use a holistic approach, based on quantitative measurements in spindles of the spatiotemporal correlation functions of microtubule density, orientation, and stresses, to identify the key processes responsible for spindle self-organization. We show that microtubule turnover and the collective effects of local microtubule interactions, mediated via motor proteins and cross-linkers, can quantitatively account for the dynamics and the structure of the spindle. We thus reveal the physical basis of spindle self-organization and provide a framework that may be useful for understanding cytoskeletal function in vivo. Twit Text FOAVip Physical basis of spindle self-organization ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468965 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25468965 #FOAvip English Wikipedia <ref>{{Cite pmid|25468965}}</ref> Physical basis of spindle self-organization #MMPMID25468965 Brugués J; Needleman D Proc Natl Acad Sci U S A 2014[Dec]; 111 (52): 18496-500 PMID25468965show ga The spindle segregates chromosomes during cell division and is composed of microtubules and hundreds of other proteins, but the manner in which these molecular constituents self-organize to form the spindle remains unclear. Here we use a holistic approach, based on quantitative measurements in spindles of the spatiotemporal correlation functions of microtubule density, orientation, and stresses, to identify the key processes responsible for spindle self-organization. We show that microtubule turnover and the collective effects of local microtubule interactions, mediated via motor proteins and cross-linkers, can quantitatively account for the dynamics and the structure of the spindle. We thus reveal the physical basis of spindle self-organization and provide a framework that may be useful for understanding cytoskeletal function in vivo. äPhysical basis of spindle self-organization (epmc).pdf DeepDyve Pubget Overpricing