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10.1073/pnas.1416652111 http://scihub22266oqcxt.onion/10.1073/pnas.1416652111 C4284548!4284548!25512501     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (52): E5651-60 Nephropedia Template TP {{tp|p=25512501|t=2014. Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator |pdf=|usr=}}{{25512501}} gab.com Text Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25512501 #FOAvip Hedgehog (Hh) signaling controls development and tissue homeostasis through the Cubitus interruptus (Ci)/glioma-associated oncogene homolog (Gli) transcription factors, and abnormal Gli activity causes congenital diseases and cancers. Here we show that Ci/Gli phosphorylation by Casein kinase 1 positively regulates Hh pathway activity, providing insights into the regulation of Ci/Gli activity. By showing that phosphorylation protects the Ci/Gli activator from premature degradation, our study not only sheds lights on how the production and degradation of Ci/Gli activator are delicately balanced to achieve optimal pathway activity but also provides the first evidence (to our knowledge) that protein degradation by the Cullin 3 family of E3 ubiquitin ligases is negatively regulated by phosphorylation. Twit Text FOAVip Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25512501 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25512501 #FOAvip English Wikipedia <ref>{{Cite pmid|25512501}}</ref> Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator #MMPMID25512501 Shi Q; Li S; Li S; Jiang A; Chen Y; Jiang J Proc Natl Acad Sci U S A 2014[Dec]; 111 (52): E5651-60 PMID25512501show ga Hedgehog (Hh) signaling controls development and tissue homeostasis through the Cubitus interruptus (Ci)/glioma-associated oncogene homolog (Gli) transcription factors, and abnormal Gli activity causes congenital diseases and cancers. Here we show that Ci/Gli phosphorylation by Casein kinase 1 positively regulates Hh pathway activity, providing insights into the regulation of Ci/Gli activity. By showing that phosphorylation protects the Ci/Gli activator from premature degradation, our study not only sheds lights on how the production and degradation of Ci/Gli activator are delicately balanced to achieve optimal pathway activity but also provides the first evidence (to our knowledge) that protein degradation by the Cullin 3 family of E3 ubiquitin ligases is negatively regulated by phosphorylation. äHedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gl(epmc).pdf DeepDyve Pubget Overpricing