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10.1002/cbic.201402439 http://scihub22266oqcxt.onion/10.1002/cbic.201402439 C4284101!4284101!25256604     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chembiochem 2014 ; 15 (17): 2563-70 Nephropedia Template TP {{tp|p=25256604|t=2014. Targeting DNA G-Quadruplexes with Helical Small Molecules |pdf=|usr=}}{{25256604}} gab.com Text Targeting DNA G-Quadruplexes with Helical Small Molecules JO: Chembiochem http://www.kidney.de/pget.php?&tw=1&pmid=25256604 #FOAvip We previously identified quinoline-based oligoamide helical foldamers and a trimeric macrocycle as selective ligands of DNA quadruplexes. Their helical structures might permit targeting of the backbone loops and grooves of G-quadruplexes instead of the G-tetrads. Given the vast array of morphologies G-quadruplex structures can adopt, this might be a way to achieve sequence selective binding. Here, we describe the design and synthesis of molecules based on macrocyclic and helically folded oligoamides. We tested their ability to interact with the human telomeric G-quadruplex and an array of promoter G-quadruplexes by using FRET melting assay and single-molecule FRET. Our results show that they constitute very potent ligands?comparable to the best so far reported. Their modes of interaction differ from those of traditional tetrad binders, thus opening avenues for the development of molecules specific for certain G-quadruplex conformations. Twit Text FOAVip Targeting DNA G-Quadruplexes with Helical Small Molecules ????Chembiochem http://www.kidney.de/pget.php?&tw=1&pmid=25256604 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25256604 #FOAvip English Wikipedia <ref>{{Cite pmid|25256604}}</ref> Targeting DNA G-Quadruplexes with Helical Small Molecules #MMPMID25256604 Müller S; Laxmi-Reddy K; Jena PV; Baptiste B; Dong Z; Godde F; Ha T; Rodriguez R; Balasubramanian S; Huc I Chembiochem 2014[Nov]; 15 (17): 2563-70 PMID25256604show ga We previously identified quinoline-based oligoamide helical foldamers and a trimeric macrocycle as selective ligands of DNA quadruplexes. Their helical structures might permit targeting of the backbone loops and grooves of G-quadruplexes instead of the G-tetrads. Given the vast array of morphologies G-quadruplex structures can adopt, this might be a way to achieve sequence selective binding. Here, we describe the design and synthesis of molecules based on macrocyclic and helically folded oligoamides. We tested their ability to interact with the human telomeric G-quadruplex and an array of promoter G-quadruplexes by using FRET melting assay and single-molecule FRET. Our results show that they constitute very potent ligands?comparable to the best so far reported. Their modes of interaction differ from those of traditional tetrad binders, thus opening avenues for the development of molecules specific for certain G-quadruplex conformations. äTargeting DNA G-Quadruplexes with Helical Small Molecules (epmc).pdf DeepDyve Pubget Overpricing