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10.15252/embj.201490101

http://scihub22266oqcxt.onion/10.15252/embj.201490101
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C4283402!4283402!25274967
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suck abstract from ncbi

pmid25274967      EMBO+J 2014 ; 33 (21): 2442-3
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  • DUBs counteract parkin for efficient mitophagy #MMPMID25274967
  • Dikic I; Bremm A
  • EMBO J 2014[Nov]; 33 (21): 2442-3 PMID25274967show ga
  • The Parkinson's disease-associated ubiquitin E3 ligase parkin impacts various cellular processes including the autophagic clearance of defective mitochondria. In this issue of The EMBO Journal, Durcan et al (2014) reveal a novel control mechanism of parkin-mediated mitophagy via the selective removal of atypical K6-linked ubiquitin chains from parkin by the deubiquitinase USP8. Together with recent studies on USP15 and USP30, this establishes a functional role for deubiquitination in mitophagy regulation.
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