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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Am+J+Nephrol 2014 ; 40 (3): 224-32 Nephropedia Template TP
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THE RELATIONSHIP BETWEEN ULTRAVIOLET LIGHT EXPOSURE AND MORTALITY IN DIALYSIS PATIENTS #MMPMID25322752
Am J Nephrol 2014[]; 40 (3): 224-32 PMID25322752show ga
Background: Emerging data suggest that reduced exposure to ultraviolet (UV) radiation is associated with increased mortality in the general population. To date, there has not been examination of the association between UV exposure and mortality in dialysis patients. Methods: We examined the association between UV index, a proxy of UV exposure, and all-cause mortality among 47,286 US dialysis patients (entry period 2001?2006, with follow-up through 2009) from a large national dialysis organization using multivariable Cox regression. The UV index was ascertained by linkage of individual patients? residential zip codes to National Oceanic and Atmospheric Administration data, and was categorized as low (0?<3), moderate (3?<5), moderate-high (5?<6), high (6?<7), and very-high (?7). In secondary analyses, we examined the UV index?mortality association within subgroups of age (<65 vs. ? 65 years old), sex, and race (white vs. non-white). Results: The study population?s meanąSD age was 60ą16 years old and included 46% women and 56% diabetics. Compared to patients residing in moderate-high UV index regions, those residing in high and very-high UV index regions had lower mortality risk: adjusted HRs 0.84 (95% CI) 0.81?0.88 and 0.83 (95% CI) 0.75?0.91, respectively. A similar inverse association between UV index and mortality was observed across all subgroups, although there was more pronounced reduction in mortality among whites vs. non-whites. Conclusion: These data suggest that dialysis patients residing in higher UV index regions have lower all-cause mortality compared to those living in moderate-high UV regions. Further studies are needed to determine mechanisms underlying the UV index?mortality association.