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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Opt+Soc+Am+A+Opt+Image+Sci+Vis 2014 ; 31 (4): A189-94 Nephropedia Template TP
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A specialized synaptic pathway for chromatic signals beneath S-cone photoreceptors is common to human, Old and New World primates #MMPMID24695169
Puller C; Manookin MB; Neitz M; Neitz J
J Opt Soc Am A Opt Image Sci Vis 2014[Apr]; 31 (4): A189-94 PMID24695169show ga
The distribution of the SNARE protein syntaxin-4 and the cation-chloride transporter NKCC were investigated in the outer plexiform layer of human retina using immunohistochemistry. Both proteins, which are proposed to be components of a GABA-mediated feedforward circuit from horizontal cells directly to bipolar cells, were enriched beneath S-cones. The expression pattern of syntaxin-4 was further analyzed in baboon and marmoset to determine if the synaptic specialization is common to primates. Syntaxin-4 was enriched beneath S-cones in both species which together with the human results indicates that this specialization may have evolved for the purpose of mediating unique color vision capacities that are exclusive to primates.