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2014 ; 31
(4
): A189-94
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Specialized synaptic pathway for chromatic signals beneath S-cone photoreceptors
is common to human, Old and New World primates
#MMPMID24695169
Puller C
; Manookin MB
; Neitz M
; Neitz J
J Opt Soc Am A Opt Image Sci Vis
2014[Apr]; 31
(4
): A189-94
PMID24695169
show ga
The distribution of the soluble NSF-attachment protein receptor protein
syntaxin-4 and the Na-K-Cl cotransporter (NKCC) were investigated in the outer
plexiform layer of human retina using immunohistochemistry. Both proteins, which
are proposed to be components of a gamma-aminobutyric acid mediated feed-forward
circuit from horizontal cells directly to bipolar cells, were enriched beneath
S-cones. The expression pattern of syntaxin-4 was further analyzed in baboon and
marmoset to determine if the synaptic specialization is common to primates.
Syntaxin-4 was enriched beneath S-cones in both species, which together with the
human results indicates that this specialization may have evolved for the purpose
of mediating unique color vision capacities that are exclusive to primates.