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10.15252/embj.201490230 http://scihub22266oqcxt.onion/10.15252/embj.201490230 C4282645!4282645!25425573     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+J 2014 ; 33 (24): 2997-3011 Nephropedia Template TP {{tp|p=25425573|t=2014. Arhgef7 promotes activation of the Hippo pathway core kinase Lats |pdf=|usr=}}{{25425573}} gab.com Text Arhgef7 promotes activation of the Hippo pathway core kinase Lats JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25425573 #FOAvip The Hippo pathway regulates tissue growth and organ size, and inactivation contributes to cancer. Signals flow through Mst/Lats kinases, which phosphorylate and promote cytoplasmic localization of the transcriptional regulators Yap and Taz to inhibit transcription. Here, we identify the multidomain-containing guanine nucleotide exchange factor (GEF) Arhgef7, or ?Pix, as a positive Hippo pathway regulator. We show that ?Pix, which localizes to the cytoplasm, binds both Lats and Yap/Taz and thereby promotes Lats-mediated phosphorylation of Yap/Taz in a GEF-independent manner. ?Pix is required downstream of both cell density sensing and actin cytoskeletal rearrangements, and we demonstrate that loss of ?Pix expression in normal mammary epithelial cells strongly reduces Yap/Taz phosphorylation, promotes nuclear localization and increases target gene expression. Conversely, increased expression of ?PIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap/Taz, promoting localization of Yap/Taz to the cytoplasm and inhibiting cell migration and proliferation. These studies thus define ?Pix as a key component that links the Hippo kinase cassette to Yap/Taz in response to multiple upstream Hippo pathway activators. Twit Text FOAVip Arhgef7 promotes activation of the Hippo pathway core kinase Lats ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25425573 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25425573 #FOAvip English Wikipedia <ref>{{Cite pmid|25425573}}</ref> Arhgef7 promotes activation of the Hippo pathway core kinase Lats #MMPMID25425573 Heidary Arash E; Song KM; Song S; Shiban A; Attisano L EMBO J 2014[Dec]; 33 (24): 2997-3011 PMID25425573show ga The Hippo pathway regulates tissue growth and organ size, and inactivation contributes to cancer. Signals flow through Mst/Lats kinases, which phosphorylate and promote cytoplasmic localization of the transcriptional regulators Yap and Taz to inhibit transcription. Here, we identify the multidomain-containing guanine nucleotide exchange factor (GEF) Arhgef7, or ?Pix, as a positive Hippo pathway regulator. We show that ?Pix, which localizes to the cytoplasm, binds both Lats and Yap/Taz and thereby promotes Lats-mediated phosphorylation of Yap/Taz in a GEF-independent manner. ?Pix is required downstream of both cell density sensing and actin cytoskeletal rearrangements, and we demonstrate that loss of ?Pix expression in normal mammary epithelial cells strongly reduces Yap/Taz phosphorylation, promotes nuclear localization and increases target gene expression. Conversely, increased expression of ?PIX in breast cancer cell lines re-couples the Hippo kinase cassette to Yap/Taz, promoting localization of Yap/Taz to the cytoplasm and inhibiting cell migration and proliferation. These studies thus define ?Pix as a key component that links the Hippo kinase cassette to Yap/Taz in response to multiple upstream Hippo pathway activators. äArhgef7 promotes activation of the Hippo pathway core kinase Lats (epmc).pdf DeepDyve Pubget Overpricing