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10.15252/embj.201489934

http://scihub22266oqcxt.onion/10.15252/embj.201489934
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C4282568!4282568!25246515
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suck abstract from ncbi


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pmid25246515      EMBO+J 2014 ; 33 (22): 2598-600
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  • Shigella hacks host immune responses by reprogramming the host epigenome #MMPMID25246515
  • Ashida H; Sasakawa C
  • EMBO J 2014[Nov]; 33 (22): 2598-600 PMID25246515show ga
  • Bacterial pathogens alter host transcriptional programs to promote infection. Shigella OspF is an essential virulence protein with a unique phosphothreonine lyase activity. A new study in The EMBO Journal (Harouz et al, 2014) reveals a novel function of OspF: targeting of heterochromatin protein 1? (HP1?) and downregulation of a subset of immune genes. These results illustrate how bacterial pathogens exploit epigenetic modifications to counteract host immune responses.
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