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10.15252/embj.201488466 http://scihub22266oqcxt.onion/10.15252/embj.201488466 C4282510!4282510 !25180231     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25180231 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon |pdf=|usr=}}{{25180231 }} gab.com Text Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25180231 #FOAvip TTLL3 and TTLL8 are tubulin glycine ligases catalyzing posttranslational glycylation of microtubules. We show here for the first time that these enzymes are required for robust formation of primary cilia. We further discover the existence of primary cilia in colon and demonstrate that TTLL3 is the only glycylase in this organ. As a consequence, colon epithelium shows a reduced number of primary cilia accompanied by an increased rate of cell division in TTLL3-knockout mice. Strikingly, higher proliferation is compensated by faster tissue turnover in normal colon. In a mouse model for tumorigenesis, lack of TTLL3 strongly promotes tumor development. We further demonstrate that decreased levels of TTLL3 expression are linked to the development of human colorectal carcinomas. Thus, we have uncovered a novel role for tubulin glycylation in primary cilia maintenance, which controls cell proliferation of colon epithelial cells and plays an essential role in colon cancer development. Twit Text FOAVip Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25180231 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25180231 #FOAvip English Wikipedia <ref>{{Cite pmid|25180231 }}</ref> Tubulin glycylases are required for primary cilia, control of cell proliferation and tumor development in colon #MMPMID25180231 Rocha C ; Papon L ; Cacheux W ; Marques Sousa P ; Lascano V ; Tort O ; Giordano T ; Vacher S ; Lemmers B ; Mariani P ; Meseure D ; Medema JP ; Bièche I ; Hahne M ; Janke C EMBO J 2014[Oct]; 33 (19 ): 2247-60 PMID25180231 show ga TTLL3 and TTLL8 are tubulin glycine ligases catalyzing posttranslational glycylation of microtubules. We show here for the first time that these enzymes are required for robust formation of primary cilia. We further discover the existence of primary cilia in colon and demonstrate that TTLL3 is the only glycylase in this organ. As a consequence, colon epithelium shows a reduced number of primary cilia accompanied by an increased rate of cell division in TTLL3-knockout mice. Strikingly, higher proliferation is compensated by faster tissue turnover in normal colon. In a mouse model for tumorigenesis, lack of TTLL3 strongly promotes tumor development. We further demonstrate that decreased levels of TTLL3 expression are linked to the development of human colorectal carcinomas. Thus, we have uncovered a novel role for tubulin glycylation in primary cilia maintenance, which controls cell proliferation of colon epithelial cells and plays an essential role in colon cancer development. |*Cell Proliferation [MESH] |Animals [MESH] |Blotting, Western [MESH] |Carcinogens/toxicity [MESH] |Cells, Cultured [MESH] |Cilia/*metabolism [MESH] |Colon/*metabolism/pathology [MESH] |Colonic Neoplasms/chemically induced/*metabolism/pathology [MESH] |Colorectal Neoplasms/metabolism/pathology [MESH] |Disease Models, Animal [MESH] |Embryo, Mammalian/cytology/metabolism [MESH] |Epithelial Cells/cytology/metabolism [MESH] |Fibroblasts/cytology/metabolism [MESH] |Glycine/*metabolism [MESH] |Humans [MESH] |Immunoenzyme Techniques [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Microtubules/metabolism [MESH] |Peptide Synthases/*physiology [MESH] |Protein Processing, Post-Translational [MESH] |RNA, Messenger/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Tubulin glycylases are required for primary cilia, control of cell pro(epmc).pdf DeepDyve Pubget Overpricing