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10.15252/embj.201488057 http://scihub22266oqcxt.onion/10.15252/embj.201488057 C4282507!4282507 !25100735     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25100735 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2014 ; 33 (19 ): 2201-15 Nephropedia Template TP {{tp|p=25100735 |t=2014. Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells |pdf=|usr=}}{{25100735 }} gab.com Text Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25100735 #FOAvip Inactivation of the retinoblastoma tumor suppressor (pRb) is a common oncogenic event that alters the expression of genes important for cell cycle progression, senescence, and apoptosis. However, in many contexts, the properties of pRb-deficient cells are similar to wild-type cells suggesting there may be processes that counterbalance the transcriptional changes associated with pRb inactivation. Therefore, we have looked for sets of evolutionary conserved, functionally related genes that are direct targets of pRb/E2F proteins. We show that the expression of NANOS, a key facilitator of the Pumilio (PUM) post-transcriptional repressor complex, is directly repressed by pRb/E2F in flies and humans. In both species, NANOS expression increases following inactivation of pRb/RBF1 and becomes important for tissue homeostasis. By analyzing datasets from normal retinal tissue and pRb-null retinoblastomas, we find a strong enrichment for putative PUM substrates among genes de-regulated in tumors. These include pro-apoptotic genes that are transcriptionally down-regulated upon pRb loss, and we characterize two such candidates, MAP2K3 and MAP3K1, as direct PUM substrates. Our data suggest that NANOS increases in importance in pRb-deficient cells and helps to maintain homeostasis by repressing the translation of transcripts containing PUM Regulatory Elements (PRE). Twit Text FOAVip Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25100735 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25100735 #FOAvip English Wikipedia <ref>{{Cite pmid|25100735 }}</ref> Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells #MMPMID25100735 Miles WO ; Korenjak M ; Griffiths LM ; Dyer MA ; Provero P ; Dyson NJ EMBO J 2014[Oct]; 33 (19 ): 2201-15 PMID25100735 show ga Inactivation of the retinoblastoma tumor suppressor (pRb) is a common oncogenic event that alters the expression of genes important for cell cycle progression, senescence, and apoptosis. However, in many contexts, the properties of pRb-deficient cells are similar to wild-type cells suggesting there may be processes that counterbalance the transcriptional changes associated with pRb inactivation. Therefore, we have looked for sets of evolutionary conserved, functionally related genes that are direct targets of pRb/E2F proteins. We show that the expression of NANOS, a key facilitator of the Pumilio (PUM) post-transcriptional repressor complex, is directly repressed by pRb/E2F in flies and humans. In both species, NANOS expression increases following inactivation of pRb/RBF1 and becomes important for tissue homeostasis. By analyzing datasets from normal retinal tissue and pRb-null retinoblastomas, we find a strong enrichment for putative PUM substrates among genes de-regulated in tumors. These include pro-apoptotic genes that are transcriptionally down-regulated upon pRb loss, and we characterize two such candidates, MAP2K3 and MAP3K1, as direct PUM substrates. Our data suggest that NANOS increases in importance in pRb-deficient cells and helps to maintain homeostasis by repressing the translation of transcripts containing PUM Regulatory Elements (PRE). |*Gene Expression Regulation [MESH] |*RNA Processing, Post-Transcriptional [MESH] |Animals [MESH] |Animals, Genetically Modified [MESH] |Blotting, Western [MESH] |Cell Proliferation [MESH] |Cells, Cultured [MESH] |Chromatin Immunoprecipitation [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila melanogaster/genetics/*metabolism [MESH] |E2F Transcription Factors/genetics/metabolism [MESH] |Humans [MESH] |MAP Kinase Kinase 3/genetics/metabolism [MESH] |MAP Kinase Kinase Kinase 1/genetics/metabolism [MESH] |MyoD Protein/genetics/metabolism [MESH] |RNA Interference [MESH] |RNA, Messenger/genetics [MESH] |RNA-Binding Proteins/genetics/*metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Retinoblastoma Protein/*physiology [MESH] |Retinoblastoma/genetics/metabolism/pathology [MESH]Post-transcriptional gene expression control by NANOS is up-regulated (epmc).pdf DeepDyve Pubget Overpricing