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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genes+Dev 2015 ; 29 (1): 63-80 Nephropedia Template TP
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Detained introns are a novel, widespread class of post-transcriptionally spliced introns #MMPMID25561496
Boutz PL; Bhutkar A; Sharp PA
Genes Dev 2015[Jan]; 29 (1): 63-80 PMID25561496show ga
Deep sequencing of embryonic stem cell RNA revealed many specific internal introns that are significantly more abundant than the other introns within polyadenylated transcripts. Boutz et al. identified thousands of these ?detained? introns (DIs) in human and mouse cell lines as well as the adult mouse liver. Drug inhibition of Clk, a stress-responsive kinase, triggered rapid splicing changes for a specific subset of DIs, altering transcript pools of >300 genes. Srsf4 regulates the splicing of some DIs, particularly in genes encoding RNA processing and splicing factors.