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10.1101/gad.247361.114

http://scihub22266oqcxt.onion/10.1101/gad.247361.114
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C4281565!4281565!25561496
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suck abstract from ncbi


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pmid25561496      Genes+Dev 2015 ; 29 (1): 63-80
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  • Detained introns are a novel, widespread class of post-transcriptionally spliced introns #MMPMID25561496
  • Boutz PL; Bhutkar A; Sharp PA
  • Genes Dev 2015[Jan]; 29 (1): 63-80 PMID25561496show ga
  • Deep sequencing of embryonic stem cell RNA revealed many specific internal introns that are significantly more abundant than the other introns within polyadenylated transcripts. Boutz et al. identified thousands of these ?detained? introns (DIs) in human and mouse cell lines as well as the adult mouse liver. Drug inhibition of Clk, a stress-responsive kinase, triggered rapid splicing changes for a specific subset of DIs, altering transcript pools of >300 genes. Srsf4 regulates the splicing of some DIs, particularly in genes encoding RNA processing and splicing factors.
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