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10.1038/nmeth.3205 http://scihub22266oqcxt.onion/10.1038/nmeth.3205 C4281301!4281301!25437436     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Methods 2015 ; 12 (1): 71-8 Nephropedia Template TP {{tp|p=25437436|t=2015. Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes |pdf=|usr=}}{{25437436}} gab.com Text Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes JO: Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=25437436 #FOAvip High-throughput methods based on chromosome conformation capture (3C) have greatly advanced our understanding of the three-dimensional (3D) organization of genomes but are limited in resolution by their reliance on restriction enzymes (REs). Here we describe a method called DNase Hi-C for comprehensively mapping global chromatin contacts that uses DNase I for chromatin fragmentation, leading to greatly improved efficiency and resolution compared to Hi-C. Coupling this method with DNA capture technology provides a high-throughput approach for targeted mapping of fine-scale chromatin architecture. We applied targeted DNase Hi-C to characterize the 3D organization of 998 lincRNA (long intergenic noncoding RNA) promoters in two human cell lines, thereby revealing that expression of lincRNAs is tightly controlled by complex mechanisms involving both super-enhancers and the polycomb repressive complex. Our results provide the first glimpse of a cell type-specific 3D organization of lincRNA genes. Twit Text FOAVip Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes ????Nat Methods http://www.kidney.de/pget.php?&tw=1&pmid=25437436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25437436 #FOAvip English Wikipedia <ref>{{Cite pmid|25437436}}</ref> Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes #MMPMID25437436 Ma W; Ay F; Lee C; Gulsoy G; Deng X; Cook S; Hesson J; Cavanaugh C; Ware CB; Krumm A; Shendure J; Blau CA; Disteche CM; Noble WS; Duan Z Nat Methods 2015[Jan]; 12 (1): 71-8 PMID25437436show ga High-throughput methods based on chromosome conformation capture (3C) have greatly advanced our understanding of the three-dimensional (3D) organization of genomes but are limited in resolution by their reliance on restriction enzymes (REs). Here we describe a method called DNase Hi-C for comprehensively mapping global chromatin contacts that uses DNase I for chromatin fragmentation, leading to greatly improved efficiency and resolution compared to Hi-C. Coupling this method with DNA capture technology provides a high-throughput approach for targeted mapping of fine-scale chromatin architecture. We applied targeted DNase Hi-C to characterize the 3D organization of 998 lincRNA (long intergenic noncoding RNA) promoters in two human cell lines, thereby revealing that expression of lincRNAs is tightly controlled by complex mechanisms involving both super-enhancers and the polycomb repressive complex. Our results provide the first glimpse of a cell type-specific 3D organization of lincRNA genes. äFine-scale chromatin interaction maps reveal the cis-regulatory landsc(epmc).pdf DeepDyve Pubget Overpricing