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10.1073/pnas.1417426112 http://scihub22266oqcxt.onion/10.1073/pnas.1417426112 C4280645!4280645!25489114     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (51): 18291-6 Nephropedia Template TP {{tp|p=25489114|t=2014. Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis |pdf=|usr=}}{{25489114}} gab.com Text Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25489114 #FOAvip A key question in fibrosing diseases is why monocytes do not become fibrocytes in healthy tissues but can become fibrocytes in fibrotic lesions. We show that fibroblasts secrete a signal that inhibits the differentiation of monocytes into fibrocytes. We identify the signal as Slit2 and show that Slit2 levels are low in fibrotic lesions. We also show that injection of Slit2 prevents fibrosis in a mouse model of lung fibrosis. The identification of Slit2 as a key signal in normal tissues that prevents entering monocytes from becoming fibrocytes represents a major advance in our understanding of the regulation of the innate immune system and how fibrosis propagates, as well as a potential novel therapeutic for fibrosis. Twit Text FOAVip Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25489114 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25489114 #FOAvip English Wikipedia <ref>{{Cite pmid|25489114}}</ref> Fibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fibrosis #MMPMID25489114 Pilling D; Zheng Z; Vakil V; Gomer RH Proc Natl Acad Sci U S A 2014[Dec]; 111 (51): 18291-6 PMID25489114show ga A key question in fibrosing diseases is why monocytes do not become fibrocytes in healthy tissues but can become fibrocytes in fibrotic lesions. We show that fibroblasts secrete a signal that inhibits the differentiation of monocytes into fibrocytes. We identify the signal as Slit2 and show that Slit2 levels are low in fibrotic lesions. We also show that injection of Slit2 prevents fibrosis in a mouse model of lung fibrosis. The identification of Slit2 as a key signal in normal tissues that prevents entering monocytes from becoming fibrocytes represents a major advance in our understanding of the regulation of the innate immune system and how fibrosis propagates, as well as a potential novel therapeutic for fibrosis. äFibroblasts secrete Slit2 to inhibit fibrocyte differentiation and fib(epmc).pdf DeepDyve Pubget Overpricing