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10.1073/pnas.1406199111 http://scihub22266oqcxt.onion/10.1073/pnas.1406199111 C4280621!4280621!25489084     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (51): 18321-6 Nephropedia Template TP {{tp|p=25489084|t=2014. Microbiota organization is a distinct feature of proximal colorectal cancers |pdf=|usr=}}{{25489084}} gab.com Text Microbiota organization is a distinct feature of proximal colorectal cancers JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25489084 #FOAvip We demonstrate, to our knowledge for the first time, that bacterial biofilms are associated with colorectal cancers, one of the leading malignancies in the United States and abroad. Colon biofilms, dense communities of bacteria encased in a likely complex matrix that contact the colon epithelial cells, are nearly universal on right colon tumors. Most remarkably, biofilm presence correlates with bacterial tissue invasion and changes in tissue biology with enhanced cellular proliferation, a basic feature of oncogenic transformation occurring even in colons without evidence of cancer. Microbiome profiling revealed that biofilm communities on paired normal mucosa cluster with tumor microbiomes but lack distinct taxa differences. This work introduces a previously unidentified concept whereby microbial community structural organization exhibits the potential to contribute to disease progression. Twit Text FOAVip Microbiota organization is a distinct feature of proximal colorectal cancers ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25489084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25489084 #FOAvip English Wikipedia <ref>{{Cite pmid|25489084}}</ref> Microbiota organization is a distinct feature of proximal colorectal cancers #MMPMID25489084 Dejea CM; Wick EC; Hechenbleikner EM; White JR; Mark Welch JL; Rossetti BJ; Peterson SN; Snesrud EC; Borisy GG; Lazarev M; Stein E; Vadivelu J; Roslani AC; Malik AA; Wanyiri JW; Goh KL; Thevambiga I; Fu K; Wan F; Llosa N; Housseau F; Romans K; Wu X; McAllister FM; Wu S; Vogelstein B; Kinzler KW; Pardoll DM; Sears CL Proc Natl Acad Sci U S A 2014[Dec]; 111 (51): 18321-6 PMID25489084show ga We demonstrate, to our knowledge for the first time, that bacterial biofilms are associated with colorectal cancers, one of the leading malignancies in the United States and abroad. Colon biofilms, dense communities of bacteria encased in a likely complex matrix that contact the colon epithelial cells, are nearly universal on right colon tumors. Most remarkably, biofilm presence correlates with bacterial tissue invasion and changes in tissue biology with enhanced cellular proliferation, a basic feature of oncogenic transformation occurring even in colons without evidence of cancer. Microbiome profiling revealed that biofilm communities on paired normal mucosa cluster with tumor microbiomes but lack distinct taxa differences. This work introduces a previously unidentified concept whereby microbial community structural organization exhibits the potential to contribute to disease progression. äMicrobiota organization is a distinct feature of proximal colorectal c(epmc).pdf DeepDyve Pubget Overpricing