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10.1073/pnas.1405994111 http://scihub22266oqcxt.onion/10.1073/pnas.1405994111 C4280603!4280603!25489076     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (51): E5508-17 Nephropedia Template TP {{tp|p=25489076|t=2014. Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo |pdf=|usr=}}{{25489076}} gab.com Text Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25489076 #FOAvip Malaria remains one of the main health threats in the developing world, with staggering social and economic costs. Resistance to artemisins, the main pharmacological tool currently available against malaria, has been widely reported. Borrelidin, a natural compound that inhibits threonyl-tRNA synthetase, has long been studied for its antibacterial and antiparasitic properties, but undesirable toxic effects prevented its further clinical development. Here we present a group of borrelidin derivatives that retain their ability to inhibit Plasmodium threonyl-tRNA synthetase but not its human homolog. Furthermore, we demonstrate, for the first time to our knowledge, that these compounds are capable of effectively clearing a Plasmodium infection in animals, curing malaria with a potency equivalent to reference drugs such as chloroquine. Twit Text FOAVip Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25489076 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25489076 #FOAvip English Wikipedia <ref>{{Cite pmid|25489076}}</ref> Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo #MMPMID25489076 Novoa EM; Camacho N; Tor A; Wilkinson B; Moss S; Marín-García P; Azcárate IG; Bautista JM; Mirando AC; Francklyn CS; Varon S; Royo M; Cortés A; Ribas de Pouplana L Proc Natl Acad Sci U S A 2014[Dec]; 111 (51): E5508-17 PMID25489076show ga Malaria remains one of the main health threats in the developing world, with staggering social and economic costs. Resistance to artemisins, the main pharmacological tool currently available against malaria, has been widely reported. Borrelidin, a natural compound that inhibits threonyl-tRNA synthetase, has long been studied for its antibacterial and antiparasitic properties, but undesirable toxic effects prevented its further clinical development. Here we present a group of borrelidin derivatives that retain their ability to inhibit Plasmodium threonyl-tRNA synthetase but not its human homolog. Furthermore, we demonstrate, for the first time to our knowledge, that these compounds are capable of effectively clearing a Plasmodium infection in animals, curing malaria with a potency equivalent to reference drugs such as chloroquine. äAnalogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria (epmc).pdf DeepDyve Pubget Overpricing