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10.1073/pnas.1415959112

http://scihub22266oqcxt.onion/10.1073/pnas.1415959112
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C4280598!4280598!25489107
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suck abstract from ncbi


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pmid25489107      Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (51): 18327-32
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  • Host-specific induction of Escherichia coli fitness genes during human urinary tract infection #MMPMID25489107
  • Subashchandrabose S; Hazen TH; Brumbaugh AR; Himpsl SD; Smith SN; Ernst RD; Rasko DA; Mobley HLT
  • Proc Natl Acad Sci U S A 2014[Dec]; 111 (51): 18327-32 PMID25489107show ga
  • Escherichia coli is the most common cause of urinary tract infections (UTI) in humans. This bacterium is a major global public health concern because it is becoming resistant to currently available antibiotics. Therefore, it is imperative to develop new treatment and prevention strategies against this bacterium. However, the processes that promote survival of this bacterium within the human urinary tract during UTI are not clearly understood. Here we identify E. coli genes that promote survival within the urinary tract during naturally occurring UTI in women. Genes identified in this study represent targets for development of new therapies against UTI caused by E. coli.
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