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10.1074/jbc.M114.593285 http://scihub22266oqcxt.onion/10.1074/jbc.M114.593285 C4276883!4276883 !25378391     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25378391 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2014 ; 289 (52 ): 36204-19 Nephropedia Template TP {{tp|p=25378391 |t=2014. Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis |pdf=|usr=}}{{25378391 }} gab.com Text Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25378391 #FOAvip Protein kinase B (Akt) is a key effector of multiple cellular processes, including cell survival. Akt, a serine/threonine kinase, is known to increase cell survival by regulation of the intrinsic pathway for apoptosis. In this study, we found that Akt modulated the mevalonate pathway, which is also linked to cell survival, by increasing Rho GTPase activation. Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser(96). This phosphorylation in macrophages increased activation of Rac1, which enhanced macrophage survival because mutation of MDD (MDDS96A) induced apoptosis. Akt-mediated activation in macrophages was specific for Rac1 because Akt did not increase activity of other Rho GTP-binding proteins. The relationship between Akt and Rac1 was biologically relevant because Akt(+/-) mice had significantly less active Rac1 in alveolar macrophages, and macrophages from Akt(+/-) mice had an increase in active caspase-9 and -3. More importantly, Akt(+/-) mice were significantly protected from the development of pulmonary fibrosis, suggesting that macrophage survival is associated with the fibrotic phenotype. These observations for the first time suggest that Akt plays a critical role in the development and progression of pulmonary fibrosis by enhancing macrophage survival via modulation of the mevalonate pathway. Twit Text FOAVip Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25378391 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25378391 #FOAvip English Wikipedia <ref>{{Cite pmid|25378391 }}</ref> Modulation of the mevalonate pathway by akt regulates macrophage survival and development of pulmonary fibrosis #MMPMID25378391 Larson-Casey JL ; Murthy S ; Ryan AJ ; Carter AB J Biol Chem 2014[Dec]; 289 (52 ): 36204-19 PMID25378391 show ga Protein kinase B (Akt) is a key effector of multiple cellular processes, including cell survival. Akt, a serine/threonine kinase, is known to increase cell survival by regulation of the intrinsic pathway for apoptosis. In this study, we found that Akt modulated the mevalonate pathway, which is also linked to cell survival, by increasing Rho GTPase activation. Akt modulated the pathway by phosphorylating mevalonate diphosphate decarboxylase (MDD) at Ser(96). This phosphorylation in macrophages increased activation of Rac1, which enhanced macrophage survival because mutation of MDD (MDDS96A) induced apoptosis. Akt-mediated activation in macrophages was specific for Rac1 because Akt did not increase activity of other Rho GTP-binding proteins. The relationship between Akt and Rac1 was biologically relevant because Akt(+/-) mice had significantly less active Rac1 in alveolar macrophages, and macrophages from Akt(+/-) mice had an increase in active caspase-9 and -3. More importantly, Akt(+/-) mice were significantly protected from the development of pulmonary fibrosis, suggesting that macrophage survival is associated with the fibrotic phenotype. These observations for the first time suggest that Akt plays a critical role in the development and progression of pulmonary fibrosis by enhancing macrophage survival via modulation of the mevalonate pathway. |Amino Acid Sequence [MESH] |Animals [MESH] |Biosynthetic Pathways [MESH] |Cell Polarity [MESH] |Cell Survival [MESH] |Cells, Cultured [MESH] |Enzyme Activation [MESH] |Humans [MESH] |Hydrogen Peroxide/metabolism [MESH] |Macrophages, Alveolar/*physiology [MESH] |Mevalonic Acid/*metabolism [MESH] |Mice, 129 Strain [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Mitochondria/metabolism [MESH] |Neuropeptides/metabolism [MESH] |Oxidative Stress [MESH] |Phosphorylation [MESH] |Protein Processing, Post-Translational [MESH] |Proto-Oncogene Proteins c-akt/*physiology [MESH] |Pulmonary Fibrosis/*enzymology/immunology [MESH] |Transforming Growth Factor beta1/metabolism [MESH]Modulation of the mevalonate pathway by akt regulates macrophage survi(epmc).pdf DeepDyve Pubget Overpricing