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10.1074/jbc.M114.598383

http://scihub22266oqcxt.onion/10.1074/jbc.M114.598383
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C4276874!4276874!25371200
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suck abstract from ncbi


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pmid25371200      J+Biol+Chem 2014 ; 289 (52): 36101-15
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  • MicroRNA-200 (miR-200) Cluster Regulation by Achaete Scute-like 2 (Ascl2): IMPACT ON THE EPITHELIAL-MESENCHYMAL TRANSITION IN COLON CANCER CELLS* #MMPMID25371200
  • Tian Y; Pan Q; Shang Y; Zhu R; Ye J; Liu Y; Zhong X; Li S; He Y; Chen L; Zhao J; Chen W; Peng Z; Wang R
  • J Biol Chem 2014[Dec]; 289 (52): 36101-15 PMID25371200show ga
  • Background: Ascl2 regulates the plasticity of EMT-MET programs in colon cancer cells.Results: Ascl2 loss of function in colon cancer cells promoted MET by derepressing miR-200 expression through a direct transcriptional mechanism.Conclusion: Ascl2 promotes EMT occurrence in part via miR-200s.Significance: This study sheds new light on preventing EMT in colon cancer.
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