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10.1074/jbc.M114.610535

http://scihub22266oqcxt.onion/10.1074/jbc.M114.610535
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suck abstract from ncbi


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pmid25406310      J+Biol+Chem 2014 ; 289 (52): 36070-88
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  • Whirlin and PDZ Domain-containing 7 (PDZD7) Proteins Are Both Required to Form the Quaternary Protein Complex Associated with Usher Syndrome Type 2* #MMPMID25406310
  • Chen Q; Zou J; Shen Z; Zhang W; Yang J
  • J Biol Chem 2014[Dec]; 289 (52): 36070-88 PMID25406310show ga
  • Background: Assembly of the protein complex associated with Usher syndrome type 2 (USH2) is unclear.Results: WHRN and PDZD7 heterodimerization and their interactions with USH2A and GPR98 are required for USH2 complex formation.Conclusion: An USH2 quaternary protein complex may exist in vivo.Significance: This study provides clues to USH2 pathogenesis and may permit the complex reconstitution for therapeutic intervention.
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