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10.1074/jbc.M114.591677

http://scihub22266oqcxt.onion/10.1074/jbc.M114.591677
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C4276865!4276865!25381443
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suck abstract from ncbi


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pmid25381443      J+Biol+Chem 2014 ; 289 (52): 35979-86
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  • Thrombin-dependent Incorporation of von Willebrand Factor into a Fibrin Network* #MMPMID25381443
  • Miszta A; Pelkmans L; Lindhout T; Krishnamoorthy G; de Groot PG; Hemker CH; Heemskerk JWM; Kelchtermans H; de Laat B
  • J Biol Chem 2014[Dec]; 289 (52): 35979-86 PMID25381443show ga
  • Background: von Willebrand factor recruits platelets into a thrombus via interactions with GPIb.Results: The cleavage of fibrinopeptides A/B is critical for the incorporation of VWF in a fibrin network. VWF incorporates independently from FXIII via its C domains.Conclusion: Fibrin-bound VWF is involved in platelet adhesion at a high shear rate.Significance: The role of VWF in platelet-dependent thrombus formation is explained.
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