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10.1074/jbc.M114.616649

http://scihub22266oqcxt.onion/10.1074/jbc.M114.616649
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C4276853!4276853!25378396
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suck abstract from ncbi


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pmid25378396      J+Biol+Chem 2014 ; 289 (52): 35849-57
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  • Klotho Up-regulates Renal Calcium Channel Transient Receptor Potential Vanilloid 5 (TRPV5) by Intra- and Extracellular N-glycosylation-dependent Mechanisms* #MMPMID25378396
  • Wolf MTF; An SW; Nie M; Bal MS; Huang CL
  • J Biol Chem 2014[Dec]; 289 (52): 35849-57 PMID25378396show ga
  • Background: Klotho is a putative sialidase that modifies the extracellular N-glycan of TRPV5 to increase its surface expression.Results: Intracellular expression of Klotho increased TRPV5 via an N-glycosylation-dependent mechanism that requires the sialidase activity of Klotho.Conclusion: Klotho up-regulates TRPV5 surface abundance by intra- and extracellular mechanisms.Significance: We investigate a novel function of Klotho to regulate intracellular protein trafficking via enzymatic activity.
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