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2015 ; 370
(1661
): 20140049
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Nanoparticles modulate surfactant protein A and D mediated protection against
influenza A infection in vitro
#MMPMID25533100
McKenzie Z
; Kendall M
; Mackay RM
; Tetley TD
; Morgan C
; Griffiths M
; Clark HW
; Madsen J
Philos Trans R Soc Lond B Biol Sci
2015[Feb]; 370
(1661
): 20140049
PMID25533100
show ga
Numerous epidemiological and toxicological studies have indicated that
respiratory infections are exacerbated following enhanced exposure to airborne
particulates. Surfactant protein A (SP-A) and SP-D form an important part of the
innate immune response in the lung and can interact with nanoparticles to
modulate the cellular uptake of these particles. We hypothesize that this
interaction will also affect the ability of these proteins to combat infections.
TT1, A549 and differentiated THP-1 cells, representing the predominant cell types
found in the alveolus namely alveolar type I (ATI) epithelial cells, ATII cells
and macrophages, were used to examine the effect of two model nanoparticles, 100
nm amine modified (A-PS) and unmodified polystyrene (U-PS), on the ability of
SP-A and SP-D to neutralize influenza A infections in vitro. Pre-incubation of
low concentrations of U-PS with SP-A resulted in a reduction of SP-A
anti-influenza activity in A549 cells, whereas at higher concentrations there was
an increase in SP-A antiviral activity. This differential pattern of U-PS
concentration on surfactant protein mediated protection against IAV was also
shown with SP-D in TT1 cells. On the other hand, low concentrations of A-PS
particles resulted in a reduction of SP-A activity in TT1 cells and a reduction
in SP-D activity in A549 cells. These results indicate that nanoparticles can
modulate the ability of SP-A and SP-D to combat viral challenges. Furthermore,
the nanoparticle concentration, surface chemistry and cell type under
investigation are important factors in determining the extent of these
modulations.
|*Nanoparticles
[MESH]
|Cell Line, Tumor
[MESH]
|Humans
[MESH]
|Influenza A virus/*physiology
[MESH]
|Pulmonary Surfactant-Associated Protein A/genetics/*metabolism
[MESH]
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