Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25401485
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Association between chronic kidney disease progression and cardiovascular
disease: results from the CRIC Study
#MMPMID25401485
Rahman M
; Xie D
; Feldman HI
; Go AS
; He J
; Kusek JW
; Lash J
; Miller ER 3rd
; Ojo A
; Pan Q
; Seliger SL
; Steigerwalt S
; Townsend RR
Am J Nephrol
2014[]; 40
(5
): 399-407
PMID25401485
show ga
BACKGROUND AND AIMS: There is limited information on the risk of progression of
chronic kidney disease (CKD) among individuals with CVD (cardiovascular disease).
We studied the association between prevalent CVD and the risk of progression of
CKD among persons enrolled in a long-term observational study. METHODS: A
prospective cohort study of 3,939 women and men with CKD enrolled in the chronic
renal insufficiency cohort (CRIC) study between June 2003 and June 2008.
Prevalent cardiovascular disease (myocardial infarction/revascularization, heart
failure, stroke, and peripheral vascular disease) was determined by self-report
at baseline. The primary outcome was a composite of either end-stage renal
disease or a 50% decline in estimated glomerular filtration rate (eGFR) from
baseline. RESULTS: One-third (1,316 of 3,939, 33.4%) of the study participants
reported a history of any cardiovascular disease, and 9.6% (n = 382) a history of
heart failure at baseline. After a median follow up of 6.63 years, 1,028 patients
experienced the primary outcome. The composite of any CVD at baseline was not
independently associated with the primary outcome (Hazard Ratio 1.04 95% CI
(0.91, 1.19)). However, a history of heart failure was independently associated
with a 29% higher risk of the primary outcome (Hazard Ratio 1.29 95% CI (1.06,
1.57)). The relationship between heart failure and risk of CKD progression was
consistent in subgroups defined by age, race, gender, baseline eGFR, and
diabetes. Neither the composite measure of any CVD or heart failure was
associated with the rate of decline in eGFR. CONCLUSIONS: Self-reported heart
failure was an independent risk factor for the development of the endpoint of
ESRD or 50% decline in GFR in a cohort of patients with chronic kidney disease.
free
free
free
