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10.1038/srep07599 http://scihub22266oqcxt.onion/10.1038/srep07599 C4274504!4274504 !25534891     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25534891 &cmd=llinks): Failed to open stream: HTTP request failed! 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Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice |pdf=|usr=}}{{25534891 }} gab.com Text Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25534891 #FOAvip TRPM7 is an unusual bi-functional protein containing an ion channel covalently linked to a protein kinase domain. TRPM7 is implicated in regulating cellular and systemic magnesium homeostasis. While the biophysical properties of TRPM7 ion channel and its function are relatively well characterized, the function of the TRPM7 enzymatically active kinase domain is not understood yet. To investigate the physiological role of TRPM7 kinase activity, we constructed mice carrying an inactive TRPM7 kinase. We found that these mice were resistant to dietary magnesium deprivation, surviving three times longer than wild type mice; also they displayed decreased chemically induced allergic reaction. Interestingly, mutant mice have lower magnesium bone content compared to wild type mice when fed regular diet; unlike wild type mice, mutant mice placed on magnesium-depleted diet did not alter their bone magnesium content. Furthermore, mouse embryonic fibroblasts isolated from TRPM7 kinase-dead animals exhibited increased resistance to magnesium deprivation and oxidative stress. Finally, electrophysiological data revealed that the activity of the kinase-dead TRPM7 channel was not significantly altered. Together, our results suggest that TRPM7 kinase is a sensor of magnesium status and provides coordination of cellular and systemic responses to magnesium deprivation. Twit Text FOAVip Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=25534891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25534891 #FOAvip English Wikipedia <ref>{{Cite pmid|25534891 }}</ref> Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivation leads to magnesium deprivation resistance phenotype in mice #MMPMID25534891 Ryazanova LV ; Hu Z ; Suzuki S ; Chubanov V ; Fleig A ; Ryazanov AG Sci Rep 2014[Dec]; 4 (ä): 7599 PMID25534891 show ga TRPM7 is an unusual bi-functional protein containing an ion channel covalently linked to a protein kinase domain. TRPM7 is implicated in regulating cellular and systemic magnesium homeostasis. While the biophysical properties of TRPM7 ion channel and its function are relatively well characterized, the function of the TRPM7 enzymatically active kinase domain is not understood yet. To investigate the physiological role of TRPM7 kinase activity, we constructed mice carrying an inactive TRPM7 kinase. We found that these mice were resistant to dietary magnesium deprivation, surviving three times longer than wild type mice; also they displayed decreased chemically induced allergic reaction. Interestingly, mutant mice have lower magnesium bone content compared to wild type mice when fed regular diet; unlike wild type mice, mutant mice placed on magnesium-depleted diet did not alter their bone magnesium content. Furthermore, mouse embryonic fibroblasts isolated from TRPM7 kinase-dead animals exhibited increased resistance to magnesium deprivation and oxidative stress. Finally, electrophysiological data revealed that the activity of the kinase-dead TRPM7 channel was not significantly altered. Together, our results suggest that TRPM7 kinase is a sensor of magnesium status and provides coordination of cellular and systemic responses to magnesium deprivation. |*Oxidative Stress [MESH] |Animals [MESH] |Embryo, Mammalian/enzymology/pathology [MESH] |Fibroblasts/*enzymology/pathology [MESH] |Magnesium Deficiency/*enzymology/genetics/pathology [MESH] |Magnesium/metabolism [MESH] |Mice [MESH] |Mice, Mutant Strains [MESH] |Protein Kinases/genetics/*metabolism [MESH] |Protein Structure, Tertiary [MESH]Elucidating the role of the TRPM7 alpha-kinase: TRPM7 kinase inactivat(epmc).pdf DeepDyve Pubget Overpricing