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10.1083/jcb.201405077 http://scihub22266oqcxt.onion/10.1083/jcb.201405077 C4274264!4274264 !25533843     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25533843 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2014 ; 207 (6 ): 717-33 Nephropedia Template TP {{tp|p=25533843 |t=2014. Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair |pdf=|usr=}}{{25533843 }} gab.com Text Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25533843 #FOAvip Heterochromatin is a barrier to DNA repair that correlates strongly with elevated somatic mutation in cancer. CHD class II nucleosome remodeling activity (specifically CHD3.1) retained by KAP-1 increases heterochromatin compaction and impedes DNA double-strand break (DSB) repair requiring Artemis. This obstruction is alleviated by chromatin relaxation via ATM-dependent KAP-1S824 phosphorylation (pKAP-1) and CHD3.1 dispersal from heterochromatic DSBs; however, how heterochromatin compaction is actually adjusted after CHD3.1 dispersal is unknown. In this paper, we demonstrate that Artemis-dependent DSB repair in heterochromatin requires ISWI (imitation switch)-class ACF1-SNF2H nucleosome remodeling. Compacted chromatin generated by CHD3.1 after DNA replication necessitates ACF1-SNF2H-mediated relaxation for DSB repair. ACF1-SNF2H requires RNF20 to bind heterochromatic DSBs, underlies RNF20-mediated chromatin relaxation, and functions downstream of pKAP-1-mediated CHD3.1 dispersal to enable DSB repair. CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities (via the plant homeodomains of CHD3.1 and ACF1), which we suggest necessitates a two-step dispersal and recruitment system regulating these opposing chromatin remodeling activities during DSB repair. Twit Text FOAVip Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25533843 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25533843 #FOAvip English Wikipedia <ref>{{Cite pmid|25533843 }}</ref> Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair #MMPMID25533843 Klement K ; Luijsterburg MS ; Pinder JB ; Cena CS ; Del Nero V ; Wintersinger CM ; Dellaire G ; van Attikum H ; Goodarzi AA J Cell Biol 2014[Dec]; 207 (6 ): 717-33 PMID25533843 show ga Heterochromatin is a barrier to DNA repair that correlates strongly with elevated somatic mutation in cancer. CHD class II nucleosome remodeling activity (specifically CHD3.1) retained by KAP-1 increases heterochromatin compaction and impedes DNA double-strand break (DSB) repair requiring Artemis. This obstruction is alleviated by chromatin relaxation via ATM-dependent KAP-1S824 phosphorylation (pKAP-1) and CHD3.1 dispersal from heterochromatic DSBs; however, how heterochromatin compaction is actually adjusted after CHD3.1 dispersal is unknown. In this paper, we demonstrate that Artemis-dependent DSB repair in heterochromatin requires ISWI (imitation switch)-class ACF1-SNF2H nucleosome remodeling. Compacted chromatin generated by CHD3.1 after DNA replication necessitates ACF1-SNF2H-mediated relaxation for DSB repair. ACF1-SNF2H requires RNF20 to bind heterochromatic DSBs, underlies RNF20-mediated chromatin relaxation, and functions downstream of pKAP-1-mediated CHD3.1 dispersal to enable DSB repair. CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities (via the plant homeodomains of CHD3.1 and ACF1), which we suggest necessitates a two-step dispersal and recruitment system regulating these opposing chromatin remodeling activities during DSB repair. |*DNA End-Joining Repair [MESH] |Adenosine Triphosphatases/*metabolism [MESH] |Animals [MESH] |Ataxia Telangiectasia Mutated Proteins/metabolism [MESH] |Cell Line, Tumor [MESH] |Chromatin Assembly and Disassembly [MESH] |Chromosomal Proteins, Non-Histone/*metabolism [MESH] |DNA Breaks, Double-Stranded [MESH] |DNA Helicases/*metabolism [MESH] |DNA-Binding Proteins [MESH] |Endonucleases [MESH] |Heterochromatin/*genetics/metabolism [MESH] |Histones/metabolism [MESH] |Mi-2 Nucleosome Remodeling and Deacetylase Complex/*metabolism [MESH] |Mice [MESH] |Molecular Sequence Data [MESH] |NIH 3T3 Cells [MESH] |Nuclear Proteins/metabolism [MESH] |Nucleosomes/metabolism [MESH] |Protein Binding [MESH] |Protein Interaction Domains and Motifs [MESH] |Transcription Factors/*metabolism [MESH]Opposing ISWI- and CHD-class chromatin remodeling activities orchestra(epmc).pdf DeepDyve Pubget Overpricing