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10.1083/jcb.201409129

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suck abstract from ncbi


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pmid25512391
      J+Cell+Biol 2014 ; 207 (6 ): 683-93
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  • KIF4A and PP2A-B56 form a spatially restricted feedback loop opposing Aurora B at the anaphase central spindle #MMPMID25512391
  • Bastos RN ; Cundell MJ ; Barr FA
  • J Cell Biol 2014[Dec]; 207 (6 ): 683-93 PMID25512391 show ga
  • The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B phosphorylates substrates including the kinesin KIF4A to regulate central spindle length. In this paper, we identify a counteracting system in which PP2A-B56? and -?, but not PP2A-B56?, -?, and -?, are maintained at the central spindle by KIF4A. Biochemical assays show that PP2A-B56? can dephosphorylate the T799 Aurora B site on KIF4A and thereby counteract the Aurora B- and microtubule-stimulated ATPase activity of KIF4A. In agreement with these observations, combined silencing of PP2A-B56? and -? resulted in increased phosphorylation of KIF4A T799 and decreased central spindle growth in anaphase B. Furthermore, reduced turnover of regulatory phosphorylation on another Aurora B substrate MKlp1 was observed, suggesting that PP2A-B56? and -? play a general role opposing Aurora B at the central spindle. KIF4A and PP2A-B56? and -? therefore create a spatially restricted negative feedback loop counteracting Aurora B in anaphase.
  • |*Anaphase [MESH]
  • |Animals [MESH]
  • |Aurora Kinase B/*metabolism [MESH]
  • |Feedback, Physiological [MESH]
  • |HeLa Cells [MESH]
  • |Humans [MESH]
  • |Kinesins/*metabolism [MESH]
  • |Protein Phosphatase 2/*metabolism [MESH]
  • |Protein Processing, Post-Translational [MESH]
  • |Protein Transport [MESH]
  • |Sf9 Cells [MESH]
  • |Spindle Apparatus/enzymology [MESH]
  • |Spodoptera [MESH]


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