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10.1021/cb500717g http://scihub22266oqcxt.onion/10.1021/cb500717g C4273974!4273974!25343321     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Biol 2014 ; 9 (12): 2905-13 Nephropedia Template TP {{tp|p=25343321|t=2014. Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target |pdf=|usr=}}{{25343321}} gab.com Text Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=25343321 #FOAvip Inflammation is a hallmark of many human diseases, including pain, arthritis, atherosclerosis, obesity and diabetes, cancer, and neurodegenerative diseases. Although there are several successfully marketed small molecules anti-inflammatory drugs such as cyclooxygenase inhibitors and glucocorticoids, many of these compounds are also associated with various adverse cardiovascular or immunosuppressive side effects. Thus, identifying novel anti-inflammatory small molecules and their targets is critical for developing safer and more effective next-generation treatment strategies for inflammatory diseases. Here, we have conducted a chemical genetics screen to identify small molecules that suppress the release of the inflammatory cytokine TNF? from stimulated macrophages. We have used an enzyme class-directed chemical library for our screening efforts to facilitate subsequent target identification using activity-based protein profiling (ABPP). Using this strategy, we have found that KIAA1363 is a novel target for lowering key pro-inflammatory cytokines through affecting key ether lipid metabolism pathways. Our study highlights the application of combining chemical genetics with chemoproteomic and metabolomic approaches toward identifying and characterizing anti-inflammatory smal molecules and their targets. Twit Text FOAVip Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=25343321 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25343321 #FOAvip English Wikipedia <ref>{{Cite pmid|25343321}}</ref> Chemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Target #MMPMID25343321 Hunerdosse D; Morris PJ; Miyamoto DK; Fisher KJ; Bateman LA; Ghazaleh JR; Zhong S; Nomura DK ACS Chem Biol 2014[Dec]; 9 (12): 2905-13 PMID25343321show ga Inflammation is a hallmark of many human diseases, including pain, arthritis, atherosclerosis, obesity and diabetes, cancer, and neurodegenerative diseases. Although there are several successfully marketed small molecules anti-inflammatory drugs such as cyclooxygenase inhibitors and glucocorticoids, many of these compounds are also associated with various adverse cardiovascular or immunosuppressive side effects. Thus, identifying novel anti-inflammatory small molecules and their targets is critical for developing safer and more effective next-generation treatment strategies for inflammatory diseases. Here, we have conducted a chemical genetics screen to identify small molecules that suppress the release of the inflammatory cytokine TNF? from stimulated macrophages. We have used an enzyme class-directed chemical library for our screening efforts to facilitate subsequent target identification using activity-based protein profiling (ABPP). Using this strategy, we have found that KIAA1363 is a novel target for lowering key pro-inflammatory cytokines through affecting key ether lipid metabolism pathways. Our study highlights the application of combining chemical genetics with chemoproteomic and metabolomic approaches toward identifying and characterizing anti-inflammatory smal molecules and their targets. äChemical Genetics Screening Reveals KIAA1363 as a Cytokine-Lowering Ta(epmc).pdf DeepDyve Pubget Overpricing