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10.1016/j.molcel.2014.11.027 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.11.027 C4273650!4273650!25526531     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2014 ; 56 (6): 723-37 Nephropedia Template TP {{tp|p=25526531|t=2014. Innate antiviral host defense attenuates TGF-? function through IRF3-mediated suppression of Smad signaling |pdf=|usr=}}{{25526531}} gab.com Text Innate antiviral host defense attenuates TGF- function through IRF3-mediated suppression of Smad signaling JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25526531 #FOAvip TGF-? signaling is essential in many processes, including immune surveillance, and its dysregulation controls various diseases, including cancer, fibrosis, and inflammation. Studying the innate host defense, which functions in most cell types, we found that RLR signaling represses TGF-? responses. This regulation is mediated by activated IRF3, using a dual mechanism of IRF3-directed suppression. Activated IRF3 interacts with Smad3, thus inhibiting TGF-?-induced Smad3 activation, and, in the nucleus, disrupts functional Smad3 transcription complexes by competing with co-regulators. Consequently, IRF3 activation by innate antiviral signaling represses TGF-?-induced growth inhibition, gene regulation and epithelial-mesenchymal transition, and the generation of Treg effector lymphocytes from naïve CD4+ lymphocytes. Conversely, silencing IRF3 expression enhances epithelial-mesenchymal transition, TGF-?-induced Treg cell differentiation upon virus infection, and Treg cell generation in vivo. We present a novel mode of regulation of TGF-? signaling by the antiviral defense, with evidence for its role in immune tolerance and cancer cell behavior. Twit Text FOAVip Innate antiviral host defense attenuates TGF- function through IRF3-mediated suppression of Smad signaling ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=25526531 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25526531 #FOAvip English Wikipedia <ref>{{Cite pmid|25526531}}</ref> Innate antiviral host defense attenuates TGF-? function through IRF3-mediated suppression of Smad signaling #MMPMID25526531 Xu P; Bailey-Bucktrout S; Xi Y; Xu D; Du D; Zhang Q; Xiang W; Liu J; Melton A; Sheppard D; Chapman HA; Bluestone JA; Derynck R Mol Cell 2014[Dec]; 56 (6): 723-37 PMID25526531show ga TGF-? signaling is essential in many processes, including immune surveillance, and its dysregulation controls various diseases, including cancer, fibrosis, and inflammation. Studying the innate host defense, which functions in most cell types, we found that RLR signaling represses TGF-? responses. This regulation is mediated by activated IRF3, using a dual mechanism of IRF3-directed suppression. Activated IRF3 interacts with Smad3, thus inhibiting TGF-?-induced Smad3 activation, and, in the nucleus, disrupts functional Smad3 transcription complexes by competing with co-regulators. Consequently, IRF3 activation by innate antiviral signaling represses TGF-?-induced growth inhibition, gene regulation and epithelial-mesenchymal transition, and the generation of Treg effector lymphocytes from naïve CD4+ lymphocytes. Conversely, silencing IRF3 expression enhances epithelial-mesenchymal transition, TGF-?-induced Treg cell differentiation upon virus infection, and Treg cell generation in vivo. We present a novel mode of regulation of TGF-? signaling by the antiviral defense, with evidence for its role in immune tolerance and cancer cell behavior. äInnate antiviral host defense attenuates TGF-? function through IRF3-m(epmc).pdf DeepDyve Pubget Overpricing