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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50): 18013-8 Nephropedia Template TP
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Type IV pili interactions promote intercellular association and moderate swarming of Pseudomonas aeruginosa #MMPMID25468980
Anyan ME; Amiri A; Harvey CW; Tierra G; Morales-Soto N; Driscoll CM; Alber MS; Shrout JD
Proc Natl Acad Sci U S A 2014[Dec]; 111 (50): 18013-8 PMID25468980show ga
The opportunistic pathogen Pseudomonas aeruginosa utilizes both its flagellum and type IV pili (TFP) to facilitate motility, attachment, and colonization. Surface motility such as swarming is thought to precede biofilm formation during infection. We combined laboratory and computational methods to probe the physical interactions of TFP during flagellar-mediated swarming and found that TFP of one cell strongly interact with TFP of other cells, which limits swarming expansion rate. Hence, wild-type P. aeruginosa use cell?cell physical interactions via their TFP to control self-organization within motile swarms. This collective mechanism of cell?cell coordination using TFP allows for moderation of swarming direction of individual cells and avoidance of a toxic environment.