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10.1073/pnas.1413397111 http://scihub22266oqcxt.onion/10.1073/pnas.1413397111 C4273407!4273407!25468977     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50): 17821-6 Nephropedia Template TP {{tp|p=25468977|t=2014. Site-specific cation release drives actin filament severing by vertebrate cofilin |pdf=|usr=}}{{25468977}} gab.com Text Site-specific cation release drives actin filament severing by vertebrate cofilin JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468977 #FOAvip Cofilin is an essential actin regulatory protein that severs filaments, which accelerates network remodeling by increasing the concentration of filament ends available for elongation and subunit exchange. The molecular basis of how cofilin binding interactions fragment filaments, which have stiffness comparable to commercial laboratory plastics, remains a central and unresolved mystery of cellular actin cytoskeleton reorganization. In this study we demonstrate that actin filament severing by vertebrate cofilin is driven by the linked dissociation of a single, site-specific cation that controls filament structure and mechanical properties, and that filament severing is an essential function of cofilin in cells. This work establishes that discrete interactions with cations serve a central regulatory function in mediating actin filament fragmentation by certain classes of severing proteins. Twit Text FOAVip Site-specific cation release drives actin filament severing by vertebrate cofilin ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25468977 #FOAvip English Wikipedia <ref>{{Cite pmid|25468977}}</ref> Site-specific cation release drives actin filament severing by vertebrate cofilin #MMPMID25468977 Kang H; Bradley MJ; Cao W; Zhou K; Grintsevich EE; Michelot A; Sindelar CV; Hochstrasser M; De La Cruz EM Proc Natl Acad Sci U S A 2014[Dec]; 111 (50): 17821-6 PMID25468977show ga Cofilin is an essential actin regulatory protein that severs filaments, which accelerates network remodeling by increasing the concentration of filament ends available for elongation and subunit exchange. The molecular basis of how cofilin binding interactions fragment filaments, which have stiffness comparable to commercial laboratory plastics, remains a central and unresolved mystery of cellular actin cytoskeleton reorganization. In this study we demonstrate that actin filament severing by vertebrate cofilin is driven by the linked dissociation of a single, site-specific cation that controls filament structure and mechanical properties, and that filament severing is an essential function of cofilin in cells. This work establishes that discrete interactions with cations serve a central regulatory function in mediating actin filament fragmentation by certain classes of severing proteins. äSite-specific cation release drives actin filament severing by vertebr(epmc).pdf DeepDyve Pubget Overpricing