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10.1073/pnas.1417527111 http://scihub22266oqcxt.onion/10.1073/pnas.1417527111 C4273403!4273403!25468975     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50): 17893-8 Nephropedia Template TP {{tp|p=25468975|t=2014. Nucleosomal promoter variation generates gene expression noise |pdf=|usr=}}{{25468975}} gab.com Text Nucleosomal promoter variation generates gene expression noise JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468975 #FOAvip Transcription is affected, in part, by the spooling of promoter DNA in nucleosomes. EM analysis of single PHO5 gene molecules from budding yeast revealed a surprising degree of variation in the promoter nucleosome configuration between individual molecules. This variation could be explained on the theory of random transitioning between alternative configurations, suggesting that genes flicker between transcriptionally conducive and unconducive states. What is the origin of this random behavior? Here, we show that the nucleosomal promoter variation cannot be reduced to molecular variation in the gene?s intracellular surroundings, that is, it is intrinsically stochastic and thus, a cause of stochastic transcription rather than its consequence). Twit Text FOAVip Nucleosomal promoter variation generates gene expression noise ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468975 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25468975 #FOAvip English Wikipedia <ref>{{Cite pmid|25468975}}</ref> Nucleosomal promoter variation generates gene expression noise #MMPMID25468975 Brown CR; Boeger H Proc Natl Acad Sci U S A 2014[Dec]; 111 (50): 17893-8 PMID25468975show ga Transcription is affected, in part, by the spooling of promoter DNA in nucleosomes. EM analysis of single PHO5 gene molecules from budding yeast revealed a surprising degree of variation in the promoter nucleosome configuration between individual molecules. This variation could be explained on the theory of random transitioning between alternative configurations, suggesting that genes flicker between transcriptionally conducive and unconducive states. What is the origin of this random behavior? Here, we show that the nucleosomal promoter variation cannot be reduced to molecular variation in the gene?s intracellular surroundings, that is, it is intrinsically stochastic and thus, a cause of stochastic transcription rather than its consequence). äNucleosomal promoter variation generates gene expression noise (epmc).pdf DeepDyve Pubget Overpricing