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10.1073/pnas.1412107111 http://scihub22266oqcxt.onion/10.1073/pnas.1412107111 C4273400!4273400 !25468973     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25468973 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50 ): E5411-9 Nephropedia Template TP {{tp|p=25468973 |t=2014. Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination |pdf=|usr=}}{{25468973 }} gab.com Text Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468973 #FOAvip To be effective, the adaptive immune response requires a large repertoire of antigen receptors, which are generated through V(D)J recombination in lymphoid precursors. These precursors must be protected from DNA damage-induced cell death, however, because V(D)J recombination generates double-strand breaks and may activate p53. Here we show that the BTB/POZ domain protein Miz-1 restricts p53-dependent induction of apoptosis in both pro-B and DN3a pre-T cells that actively rearrange antigen receptor genes. Miz-1 exerts this function by directly activating the gene for ribosomal protein L22 (Rpl22), which binds to p53 mRNA and negatively regulates its translation. This mechanism limits p53 expression levels and thus contains its apoptosis-inducing functions in lymphocytes, precisely at differentiation stages in which V(D)J recombination occurs. Twit Text FOAVip Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468973 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25468973 #FOAvip English Wikipedia <ref>{{Cite pmid|25468973 }}</ref> Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination #MMPMID25468973 Rashkovan M ; Vadnais C ; Ross J ; Gigoux M ; Suh WK ; Gu W ; Kosan C ; Möröy T Proc Natl Acad Sci U S A 2014[Dec]; 111 (50 ): E5411-9 PMID25468973 show ga To be effective, the adaptive immune response requires a large repertoire of antigen receptors, which are generated through V(D)J recombination in lymphoid precursors. These precursors must be protected from DNA damage-induced cell death, however, because V(D)J recombination generates double-strand breaks and may activate p53. Here we show that the BTB/POZ domain protein Miz-1 restricts p53-dependent induction of apoptosis in both pro-B and DN3a pre-T cells that actively rearrange antigen receptor genes. Miz-1 exerts this function by directly activating the gene for ribosomal protein L22 (Rpl22), which binds to p53 mRNA and negatively regulates its translation. This mechanism limits p53 expression levels and thus contains its apoptosis-inducing functions in lymphocytes, precisely at differentiation stages in which V(D)J recombination occurs. |Analysis of Variance [MESH] |Animals [MESH] |Cell Death/physiology [MESH] |Chromatin Immunoprecipitation [MESH] |Flow Cytometry [MESH] |Gene Expression Regulation/genetics/*physiology [MESH] |Genetic Vectors/genetics [MESH] |Immunoblotting [MESH] |Immunoprecipitation [MESH] |Lymphoid Progenitor Cells/*physiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Nuclear Proteins/genetics/*metabolism [MESH] |Protein Biosynthesis/genetics/*physiology [MESH] |Protein Inhibitors of Activated STAT/genetics/*metabolism [MESH] |RNA-Binding Proteins/*metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Ribosomal Proteins/*metabolism [MESH] |Tumor Suppressor Protein p53/*metabolism [MESH] |Ubiquitin-Protein Ligases [MESH]Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cell(epmc).pdf DeepDyve Pubget Overpricing