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10.1073/pnas.1421438111

http://scihub22266oqcxt.onion/10.1073/pnas.1421438111
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C4273385!4273385!25453096
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suck abstract from ncbi


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pmid25453096      Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50): E5429-38
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  • Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells #MMPMID25453096
  • Samanta D; Gilkes DM; Chaturvedi P; Xiang L; Semenza GL
  • Proc Natl Acad Sci U S A 2014[Dec]; 111 (50): E5429-38 PMID25453096show ga
  • Breast cancer stem cells play essential roles in tumor growth, maintenance, and recurrence after chemotherapy. We report that treatment of human breast cancer cells with chemotherapy results in an enrichment of breast cancer stem cells among the surviving cells, which is dependent upon the activity of hypoxia-inducible factors (HIFs). Studies in mouse tumor models suggest that combining chemotherapy with drugs that block HIF activity may improve the survival of breast cancer patients.
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