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10.1073/pnas.1407792111 http://scihub22266oqcxt.onion/10.1073/pnas.1407792111 C4273376!4273376!25516983     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50): E5401-10 Nephropedia Template TP {{tp|p=25516983|t=2014. Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms |pdf=|usr=}}{{25516983}} gab.com Text Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25516983 #FOAvip Myeloproliferative neoplasms (MPN) are chronic hematopoietic disorders characterized by clonal proliferation of mature myeloid elements. A subset of MPNs transforms to acute myeloid leukemia (AML). The mechanisms and pathways that contribute to transformation from MPN to AML have not been well delineated. We have characterized the somatic mutational spectrum of post-MPN AML and demonstrate that somatic tumor protein 53 (TP53) mutations are common in JAK2V617F-mutant, post-MPN AML but not in chronic-phase MPN. We demonstrate that expression of JAK2V617F combined with Tp53 loss in a murine model leads to fully penetrant AML in vivo. We have characterized this model and used it to test therapeutic strategies. These data reveal novel insights into the pathogenesis of, and potential therapeutic strategies for, leukemic transformation. Twit Text FOAVip Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25516983 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25516983 #FOAvip English Wikipedia <ref>{{Cite pmid|25516983}}</ref> Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms #MMPMID25516983 Rampal R; Ahn J; Abdel-Wahab O; Nahas M; Wang K; Lipson D; Otto GA; Yelensky R; Hricik T; McKenney AS; Chiosis G; Chung YR; Pandey S; van den Brink MRM; Armstrong SA; Dogan A; Intlekofer A; Manshouri T; Park CY; Verstovsek S; Rapaport F; Stephens PJ; Miller VA; Levine RL Proc Natl Acad Sci U S A 2014[Dec]; 111 (50): E5401-10 PMID25516983show ga Myeloproliferative neoplasms (MPN) are chronic hematopoietic disorders characterized by clonal proliferation of mature myeloid elements. A subset of MPNs transforms to acute myeloid leukemia (AML). The mechanisms and pathways that contribute to transformation from MPN to AML have not been well delineated. We have characterized the somatic mutational spectrum of post-MPN AML and demonstrate that somatic tumor protein 53 (TP53) mutations are common in JAK2V617F-mutant, post-MPN AML but not in chronic-phase MPN. We demonstrate that expression of JAK2V617F combined with Tp53 loss in a murine model leads to fully penetrant AML in vivo. We have characterized this model and used it to test therapeutic strategies. These data reveal novel insights into the pathogenesis of, and potential therapeutic strategies for, leukemic transformation. äGenomic and functional analysis of leukemic transformation of myelopro(epmc).pdf DeepDyve Pubget Overpricing