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10.1073/pnas.1415316111 http://scihub22266oqcxt.onion/10.1073/pnas.1415316111 C4273347!4273347!25468970     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50): 18007-12 Nephropedia Template TP {{tp|p=25468970|t=2014. Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels |pdf=|usr=}}{{25468970}} gab.com Text Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468970 #FOAvip Brain arteriovenous malformations are focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. They can cause ischemia, hemorrhage, disability, and death, particularly in young people, accounting for 50% of childhood stroke. The molecular etiology of the disease remains poorly understood, hindering the development of therapeutic treatments. Here, we report that, in an animal model, the lesion arises from the enlargement of capillary-like vessels. Notch signaling in the endothelium of microvasculature and veins is critical for the disease initiation by increasing cell areas but not proliferation. Blood flow mediates disease progression by a positive feedback of increasing flow and vessel diameter. Our data shed light on the mechanism underlying the pathogenesis of this devastating disease. Twit Text FOAVip Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25468970 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25468970 #FOAvip English Wikipedia <ref>{{Cite pmid|25468970}}</ref> Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels #MMPMID25468970 Murphy PA; Kim TN; Huang L; Nielsen CM; Lawton MT; Adams RH; Schaffer CB; Wang RA Proc Natl Acad Sci U S A 2014[Dec]; 111 (50): 18007-12 PMID25468970show ga Brain arteriovenous malformations are focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. They can cause ischemia, hemorrhage, disability, and death, particularly in young people, accounting for 50% of childhood stroke. The molecular etiology of the disease remains poorly understood, hindering the development of therapeutic treatments. Here, we report that, in an animal model, the lesion arises from the enlargement of capillary-like vessels. Notch signaling in the endothelium of microvasculature and veins is critical for the disease initiation by increasing cell areas but not proliferation. Blood flow mediates disease progression by a positive feedback of increasing flow and vessel diameter. Our data shed light on the mechanism underlying the pathogenesis of this devastating disease. äConstitutively active Notch4 receptor elicits brain arteriovenous malf(epmc).pdf DeepDyve Pubget Overpricing