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10.1073/pnas.1413915111 http://scihub22266oqcxt.onion/10.1073/pnas.1413915111 C4273345!4273345!25475856     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (50): 17971-6 Nephropedia Template TP {{tp|p=25475856|t=2014. Fc?RIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis |pdf=|usr=}}{{25475856}} gab.com Text Fc RIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25475856 #FOAvip Antibody (IgG) plays an important role in defense against infection and in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Low affinity-activating fragment crystallizable gamma receptors (Fc?Rs) that bind IgG immune complexes (ICs) mediate many effector functions of antibody and are controlled by an inhibitory receptor, Fc?RIIb. Here we show a previously unappreciated role for IC in driving an expansion of lymphatic conduits within lymph nodes. This was dependent on macrophage VEGF-A production and inhibited by Fc?RIIb. Lymphangiogenesis and VEGF-A were increased in the lymph nodes of mice with arthritis and SLE and in macrophages obtained from people with a SLE-associated, defunctioning polymorphism in FCGR2B. These findings have implications for the pathogenesis and treatment of autoimmune diseases. Twit Text FOAVip Fc RIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25475856 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25475856 #FOAvip English Wikipedia <ref>{{Cite pmid|25475856}}</ref> Fc?RIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis #MMPMID25475856 Clatworthy MR; Harford SK; Mathews RJ; Smith KGC Proc Natl Acad Sci U S A 2014[Dec]; 111 (50): 17971-6 PMID25475856show ga Antibody (IgG) plays an important role in defense against infection and in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Low affinity-activating fragment crystallizable gamma receptors (Fc?Rs) that bind IgG immune complexes (ICs) mediate many effector functions of antibody and are controlled by an inhibitory receptor, Fc?RIIb. Here we show a previously unappreciated role for IC in driving an expansion of lymphatic conduits within lymph nodes. This was dependent on macrophage VEGF-A production and inhibited by Fc?RIIb. Lymphangiogenesis and VEGF-A were increased in the lymph nodes of mice with arthritis and SLE and in macrophages obtained from people with a SLE-associated, defunctioning polymorphism in FCGR2B. These findings have implications for the pathogenesis and treatment of autoimmune diseases. äFc?RIIb inhibits immune complex-induced VEGF-A production and intranod(epmc).pdf DeepDyve Pubget Overpricing